
microLife
@microlifejrnl
The journal of the European Academy of Microbiology (EAM) | An Open Access @FEMSmicro journal covering all aspects of #microbiology
ID: 1417811294992875521
https://academic.oup.com/microlife 21-07-2021 11:43:00
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🦠 The “French Phage Network” unites researchers, industry & clinicians to share the latest in #phage ecology, evolution, structure, therapy & #biotech! 🌍🔬 Report by Bacteriophage Lab Institut Pasteur, Pellegri Callypso and colleagues ✨ Phages.fr buff.ly/fRn4wbL






🦠 #Paeruginosa survival inside macrophages is a major challenge. Using mathematical modeling, Dimitriew & Schuster (Universität Jena) unveiled how PA defends against the immune system and pinpointed potential new drug targets to combat #infections. 🔬♟️ buff.ly/XZeC64x


🦠 Dreaming of tracking real-time colony growth? Selina Rust, Lennart Randau built SMARTIS for you: a remote-controlled, smartphone-based time-lapse imaging system. 🔬📱 Early heterogeneity spotted within hours for cells with Type IV-A1 CRISPR-Cas activity! buff.ly/lsXhKvG





🦠Bacteria and archaea fine-tune CRISPR immunity by silencing ‘extraneous’ CRISPR RNAs (ecrRNAs) that could sabotage defense. Weinberg’s lab UNIVERSITÄT LEIPZIG & Beisel Lab reveal 3 strategies in type II-C systems that mitigate ecrRNAs and maintain precision.✂️🧬 buff.ly/xcSOMpG




The methylcitrate cycle (MCC) – a lesser-known cousin of the TCA cycle – plays a key role in pathogenic fungi & bacteria. 🦠✨ Absent in humans, Korn and colleagues Universität Jena highlight its potential as a new #DrugTarget & #biotech tool. buff.ly/TZNGfZS



Why do #phages make short #endolysin isoforms? 🧬🦠 Matthew Dunne team in ETH Zürich, using Staph φ2638A, reveals both full-length and short variants form heterodimers to boost lysis & phage release—explaining conserved internalTSSs in phage genomes! buff.ly/1I0H9ya


#Actinomycetes are rich in #CRISPR-Cas systems—many with unique features—yet their roles remain largely unknown.🧬 Mitousis et al. review highlights the need to explore these systems to unlock better genetic tools & new #naturalproducts.🦠 ⚙️ Universität Tübingen buff.ly/84sehNp
