Lactate production is important to regenerate NAD+ during anaerobic growth like fermentation (like the microenvironment of a plaque or cavity). How well will it compete with microbes that do not have this fitness disadvantage? Seems like they aren't considering ecology here.

Congratulations Andreas Bäumler of UC Davis, newly inducted #NASmember! #NAS161 #microbiology #immunology

Congrats to the greatest PhD mentor of all time Andreas Baumler

Excited to share our new review written by the amazing duo grad student Nic Shealy and undergrad Madi Baltagulov discussing the role of the small intestine microbiota in intestinal diseases. onlinelibrary.wiley.com/doi/10.1111/mm…

#probiotics: Uncovering the mechanisms of sorbitol intolerance, with Dr. Jee-Yon Lee MD PhD isappscience.org/?p=7393

This is such a cool story on host-pathogen-microbiome interactions. Congrats to all authors involved!

Check out our new paper on how Epithelial Hypoxia maintains colonization resistance against the fungal pathogens Candida albicans. Details on our new metabolomics web app, omuShiny, are also there!

We found that anaerobiosis limits growth of Candida in the healthy gut, but disruption of anaerobiosis by antibiotics drives an intestinal bloom. Pharmacological restoration of anaerobiosis using drugs that stimulate epithelial oxygen consumption prevents this bloom.

An anti-inflammatory curbs spread of fungi causing serious blood infections scienmag.com/an-anti-inflam…

Hypoxia limits C. albicans. Anaerobiosis limits growth of C. albicans. #Antibiotic disruption of anaerobiosis drives C. albicans bloom, which can be prevented w/probiotic bacteria that respire oxygen or pharmacological restoration of anaerobiosis Andreas Baumler cell.com/cell-host-micr…

I still refuse to use Pseudomonadota and Bacillota 😂. Enterobacteriaceae and Clostridia, my two favorites, get no love from the taxonomists.

Are you at #ASMicrobe and interested in host-microbiota interactions? Don’t miss this awesome session tomorrow morning with talks from Wenhan Zhu , Liz Johnson and selected abstracts. 😊

Salmonella overcomes colonization resistance when the microbiota is compositionally intact by disrupting epithelial hypoxia, which fuels outgrowth by catabolizing simple sugars via aerobic respiration and mixed acid fermentation Cell Host & Microbe Andreas Baumler cell.com/cell-host-micr…

Salmonella breaks colonization resistance Salmonella overcomes colonization resistance w/intact microbiota by disrupting epithelial hypoxia. Outgrowth fueled by catabolizing simple sugars via combo of aerobic respiration & mixed acid fermentation Andreas Baumler cell.com/cell-host-micr…

Excited to announce the launch of the Center for Microbial Medicine CHOP Research! This new translational Center of Emphasis at CHOP will be dedicated to finding cures and improving pediatric health through the lens of the microbiome research.chop.edu/cornerstone-bl…

I’m proud to share our recent publication describing the development of a multivalent mRNA-LNP vaccine for C. difficile that incorporates targets across C. diff’s complex life cycle science.org/doi/10.1126/sc…

Delighted to share our work developing an mRNA vaccine for C. difficile, published today in Science Magazine. This study with The Drew Weissman Lab was co-led by two truly amazing scientists: Alexa Sem from the Zackular lab and Mohamad-Gabriel Alameh (now at CHOP Research)! science.org/doi/10.1126/sc…

Excited that our manuscript "CCL28 modulates neutrophil responses during infection with mucosal pathogens" is out in eLife - the journal: doi.org/10.7554/eLife.…; led by the super talented Greg Walker and Araceli Perez-Lopez, with the help of many collaborators (incl. ᐯIᑕTOᖇ ᑎIᘔET and team)

Excited to share our latest work led by Joshua Soto Ocaña & Elliot Friedman in mBio today! Together with Gary Wu's team, we suggest metals may be an important nutritional factor shaping early life microbial ecology. journals.asm.org/doi/10.1128/mb…

Salmonella triggers amino acid malabsorption in the ileum to create a a wave of lysine entering the cecum. Decarboxylation of lysine buffers the cytosol to protect against short-chain fatty acids, enabling the pathogen to invade the cecal ecosystem. pnas.org/doi/10.1073/pn…