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WOO for Wuo!🎊 Mike Wuo et al design a new probe to discover how the mycobacterial cell wall rearranges itself in the presence of antibiotics. Why won't the lipid bilayer just let these antibiotics in?? Find out here: biorxiv.org/content/10.110…

Fun collaboration spearheaded by Mike Wuo with Eric Rubin Lab the Hung group Broad Institute, and the Garner group (Ethan Garner) to image the mycobacterial lipids #TB in the presence of #antibiotics (Rifampicin results in outer membrane vesicles below). biorxiv.org/content/10.110…

Super fun collab with Mike Wuo. We image mycobacteria treated w/ a mycolic acid integration probe and see antibiotic-mediated ejection of cell membrane. Different drugs induce secretory vesicles with different morphology and immunomodulatory effects on macrophages #tuberculosis

Here is the 2007 "Survey of Sam's Syntheses", compiled with input from the entire Danishefsky research family. It needs to be updated and corrected. Any volunteers? drive.google.com/file/d/12eOqxP… Pitt Chemistry,Yale Chemistry, @sloan_kettering, Total Syntheses

Some fun weekend reading, anyone? Amanda Dugan Amanda Peiffer and Laura Kiessling discuss methodological advances to better understand glycans and their interactions in both hosts and pathogens.

Protein Cofactor Mimics Disrupt Essential Chaperone Function in Stressed Mycobacteria pubs.acs.org/doi/10.1021/ac… Congrats to Brock and Johnny on their work (Woo hoo!) on rational protein chaperone inhibitors...

My boy Charlie Dulberger with the 🔥

Amanda Dugan, Mike Wuo, mel halim, and team in ACS Central Science describe a method to rapidly screen for virus-neutralizing antibodies using glycan-binding proteins. The approach can even distinguish Abs from different mRNA vaccines #SARSCoV2science pubs.acs.org/doi/10.1021/ac…

Chemists’ technique reveals whether antibodies neutralize SARS-CoV-2: The method could enable a rapid test to determine whether individuals are producing antibodies that help protect against Covid-19. mitsha.re/Uo8E50Okooy