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Extremely grateful for Yavin’s mentorship and guidance. He is a remarkable mentor, scientist, and individual. Congrats and well-deserved! Yavin Shaham

Adolescent nicotine administration increases nicotinic acetylcholine receptor binding and functional connectivity in specific cortico-striatal-thalamic circuits. Awesome work by Robin Keeley, ⁦@harrylu_TMS⁩ ⁦⁦mike michaelides⁩ and Elliot Stein academic.oup.com/braincomms/adv…

New lab paper led by 1st author @eventrig (an exceptional NIDA Postbac currently applying to PhD programs) in collabo with jordi bonaventura. Brain exposure of opioids is a critical but somewhat neglected area of research with important mechanistic & human therapeutic implications.

Can't block P-gp and then give people oliceridine. No bueno. PET with [11C]dlop is prob the way to go. Baby steps. Trevena interpreted the in vitro interaction they saw of oliceridine with P-gp as being "modest". Can't rely solely on in vitro data for in vivo implications.

Well funded private biotech Kriya acquired Redpin Therapeutics— this will turbocharge the development of chemogenetic gene therapies. businesswire.com/news/home/2022…

Check it out! Our latest collaborative effort it's finally out in Science Advances. Kudos to Oscar Solis, mike michaelides lab, Jain Lab @ Hopkins and all the collaborators for putting this paper together during a global pandemic. science.org/doi/10.1126/sc….

MM vs MM mike michaelides Matt MacDonald #ACNP2022

biologicalpsychiatryjournal.com/article/S0006-…

🧵I'm happy to share our latest publication is out now in Biological Psychiatry! Quite the holiday present. Thanks to mike michaelides jordi bonaventura @eventrig Reece Budinich Gomez, Juan @diianni_t Carlos Zarate, MD Yavin Shaham and all other coauthors! biologicalpsychiatryjournal.com/article/S0006-…

New collaborative paper from Todd Gould’s lab w Kyle Brown, Panos Zanos & other collaborators showing that benzethonium, the preservative in injectable ketamine, produces in vitro physiological effects & interacts with a number of neurotransmitter receptors sciencedirect.com/science/articl…

Baltimore Brain Series abstract submission is now open for Spring 2023! Seminars will be hybrid this year. Speakers will be invited onto campus for an in-person seminar with Zoom links given to the other institutions! Univ of Maryland School of Medicine Neuroscience NIDAnews Hopkins Neuroscience Hopkins Neuro Grad Students

Paper Preview: A new CRE/DRE dual recombinase transgenic mouse reveals synaptic zinc release from non-lemniscal thalamic neurons that inhibits NMDARs of PT auditory cortical neurons. Excellent collaboration with my friend mike michaelides. To appear soon in Sci Adv. Thinc-Zinc!

New paper describing the generation of a dual recombinase ZnT3 mouse and its use to reveal a novel synaptic zinc-mediated thalamocortical pathway. Thank you my friend Thanos Tzounopoulos and Manoj Kumar for the wonderful collaboration! With Oscar Solis @eventrig @falloncurryy

Happy to share our Hot Topics article on the role of mu opioid receptors in the therapeutic potential and abuse liability of ketamine which highlights our recent paper in Biological Psychiatry. Thank you to the editors of Neuropsychopharmacology for the invitation rdcu.be/dgGui

New Hot Topics as part of Neuropsychopharmacology 2024 Reviews issue #NPPR2024, "Exploring the role of mu opioid receptors in the therapeutic potential and abuse liability of (S)-ketamine" from Marjorie Rose Levinstein mike michaelides nature.com/articles/s4138…

Very happy to share this resource to the community: science.org/doi/10.1126/sc…

Dopplegangers spotted at the #ACNP2023 poster session mike michaelides Matt MacDonald

Intriguing paper: Unique pharmacodynamic properties and low abuse liability of the µ-opioid receptor ligand (S)-methadone nature.com/articles/s4138…

With all the holiday chaos, I hadn’t shared. Our big collaboration is out now in Molecular Psychiatry “Unique pharmacodynamic properties and low abuse liability of the μ-opioid receptor ligand (S)-methadone”! One of my favorite Christmas gifts this year 1/ rdcu.be/duqdR