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Excited to share this Spotlight in Molecular Cell from my current lab rotation, highlighting exciting work on a link between cancers with mutations in metabolic genes and DNA repair from @parkersulkowski and colleagues authors.elsevier.com/a/1bX5k3vVUPDf…

Amplifying the Noise: Oncometabolites Mask an Epigenetic Signal of DNA Damage dlvr.it/RdJMmp

Don’t miss this virtual info session next week about UT Southwestern MSTP and hear from CRI member Alex Sternisha, an MSTP student in the McBrayer lab about his experience.

Meet Alex Sternisha, an M.D./Ph.D. student in the McBrayer lab! He studies how small molecules that are produced and consumed by living cells can control the fate of individual cells by shaping genomic DNA structure. Learn more about his work & #LifeAtCRI cri.utsw.edu/life-at-the-in…

new preprint just dropped 👀 a thread:

Congratulations to McBrayer lab postdoc Yi Xiao (Yi Xiao) on receiving the prestigious HFSP’s long-term fellowship! This grant will help him investigate the mechanisms of metabolic-epigenetic crosstalk that promote brain tumor formation. cri.utsw.edu/mcbrayer-lab-m…

Are you a scientifically-minded professional with flow cytometry experience who enjoys helping others make discoveries? Sean Morrison lab & Children’s Research Institute at UT Southwestern are hiring a research specialist to manage the flow cytometry core. Learn more below. #ScienceCareers jobs.utsouthwestern.edu/job/15618445/s…

Scientists in the McBrayer lab developed a new method to create surgically-explanted organoids from patients with #BrainCancer, resolving a long-standing roadblock to studying lower-grade brain tumors in the lab. Learn about the study in Neuro-Oncology. ⤵️ bit.ly/3lBdNNN

New research in Cancer Cell from the McBrayer lab identified the de novo pyrimidine nucleotide synthesis pathway as a targetable vulnerability in IDH1 mutant brain tumors. These findings establish the basis of a clinical trial expected to begin next year. cri.utsw.edu/researchers-id…

Online Now: De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma dlvr.it/SWsG4m

Was great to have the chance to present our recent work from the McBrayer lab at #KSTumorMetabolism22 – thanks to the organizers, Sam, @RJDLab, our collaborators, and everyone at Children’s Research Institute at UT Southwestern! Check out the paper at doi.org/10.1016/j.ccel…

The September issue of Cancer Cell is out! Read and spread the news: cell.com/cancer-cell/is…

NEW content online! Gliomas lean on pyrimidines dlvr.it/SYkf3S

Excited to share our new review covering recent work on nucleotide metabolism in cancer! Free access link here: authors.elsevier.com/a/1h2%7E0_sivv…

In the latest edition of Cell Press Trends in Cancer, the McBrayer lab at Children’s Research Institute at UT Southwestern reviews the emerging roles that nucleotides play in cancer metabolism. Learn more at sciencedirect.com/science/articl…

Our lab is hiring at all levels! We’ve got multiple cool projects looking at metabolism, placenta biology, chromatin regulation. Click here to read more: labs.utsouthwestern.edu/solmonson-lab And email me at [email protected] if you are interested!

New in @sciencemagazine! Our study reveals how mutant IDH1 inhibition activates tumor immunity by inducing dsDNA sensing. Read more: science.org/doi/10.1126/sc… #CancerResearch #Cholangiocarcinoma #IDH1 1/n

Collab🚨: CRI's McBrayer Lab contributed to a discovery published in Science Magazine from Rob Manguso & Bardeesy Lab at Mass General Cancer Center that defines a new #cancer-causing mechanism associated with IDH1 mutations (the most commonly mutated metabolic gene across cancers). From

Today's #MondayMotivation is courtesy CRI's McBrayer Lab: Congrats Milan Savani for successfully defending your dissertation! Dr. Savani's family and lab mates joined to celebrate. Next steps: publishing his #research & finishing his M.D. UT Southwestern Medical Center 🎉 #relentlessdiscovery