Inspiring work on the dynamic chromatin interaction of PRC1 constituents in living mESCs by Miles Huseyin is out! Worth a read - definitely puts biochemistry in perspective nature.com/articles/s4146…

Congratulations Miles Huseyin and Rob Klose! very important work showing that single-molecule live-cell measurements are crucial to understand dynamic gene regulation.

Excited to share our work published in Science Magazine led by our DPhil @LisaRodermund, jointly supervised by Lothar Schermelleh and us. (1/3) science.sciencemag.org/content/372/65…

So excited to see my PhD work published in Science today! Many thanks to everyone who contributed from the Brockdorff Lab and Lothar Schermelleh lab! We developed RNA-SPLIT for super-resolved insight into Xist RNA kinetics and behavior. 🧬🔬

Excited to share our new preprint further elucidating the gene silencing pathways downstream of Xist RNA: biorxiv.org/content/10.110… Experiments led by Joe @_joebowness and Tatyana with contributions from other lab members. Key points… (1/4)

Great to see @emmy_dimitrova’s work out this morning. Nice team effort and fun working with deWitLab. New insight into the role of CDK-Mediator and #polycomb in poising/priming genes for induction. Tweetorial and link to paper below👇

Great to see Amy Hughes work on bioRxiv! If you are interested in CpG islands and transcription regulation check this out. Amy finds an interesting new role for CpG islands and SET1 complexes in counteracting termination by ZC3H4 complexes.👇 biorxiv.org/content/10.110…

Really excited to see some of the work from my PhD in the Rob Klose lab on BioRxiv! Thank you to all of the co-authors and all members of the Klose lab, past and present, for all of the help along the way!

Region Capture Micro-C reveals coalescence of enhancers and promoters into nested microcompartments biorxiv.org/cgi/content/sh… #bioRxiv

(1/n) Excited to share preprint by Viraat Goel Miles Huseyin We develop Region-Capture Micro-C (RCMC) By focusing on specific regions, we generate the deepest 3D genome maps thus far We see coalescence of enhancer and promoters into “microcompartments” biorxiv.org/content/10.110…

Really happy to see Viraat Goel's preprint with Anders Sejr Hansen up on bioRxiv! Really glad I had the chance to take part in putting this together! If you're interested in 3C methods, check out our contact maps! biorxiv.org/content/10.110…

Check out our new preprint by Viraat Goel Miles Huseyin "Region Capture Micro-C reveals coalescence of enhancers and promoters into nested microcompartments" biorxiv.org/content/10.110… and see the thread below:

From Anders Sejr Hansen, Viraat Goel & Miles Huseyin, and team develop Region Capture Micro-C to generate the deepest 3D genome maps reported thus far. Thank you for using Twist custom panels and probes to support your research! Region Capture Micro-C… bit.ly/3g9YQD3

1/n Our Region Capture Micro-C (RCMC) preprint by Viraat Goel Miles Huseyin is out today in Nature Genetics at rdcu.be/dbEuM See also MIT News story at news.mit.edu/2023/unprecede… with a nice 2-min video explainer youtube.com/watch?v=oybAJI… More details below:

Thrilled to share that my first research paper is now published! 3D genomics has struggled to cost-effectively resolve fine-scale enhancer-promoter interactions; RCMC overcomes this bottleneck. Extremely grateful to Miles Huseyin & Anders Sejr Hansen for their support & guidance.

Excited to see Aleksander Szczurek, @emmy_dimitrova, and Jess Kelley 's paper on bioRxiv. Hope you enjoy this deep dive into Polycomb-mediated transcriptional repression using live single-cell imaging approaches! #polycomb biorxiv.org/content/10.110…

1/6 I'm pleased to announce new preprint on how Polycomb system controls transcription in living cells by myself, Rob Klose, @emmy_dimitrova , and Jess Kelley biorxiv.org/content/10.110…

Research Highlight by Lei Tang: Anders Sejr Hansen and colleagues integrated an enrichment strategy to Micro-C to obtain fine-scale resolution 3D genome maps. nature.com/articles/s4159…

I’m excited to share that my PhD paper is now published in Nature Communications! I’m grateful for the support of all collaborators, in particular my advisor Davide Mazza, Alessia Loffreda, and Emanuele Colombo. See this thread for more details, and read the paper at nature.com/articles/s4146…

Putative Looping Factor ZNF143/ZFP143 is an Essential Transcriptional Regulator with No Looping Function biorxiv.org/cgi/content/sh… #biorxiv_genetic