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Science's special issue on #TheHumanGenome examines successes in applying research in the human genome to understanding human evolution, cancer, polygenic traits, and functional genomics. It also highlights research ground yet to cover. Learn more: fcld.ly/ayxu49h

New preprint on developing a sensitive Simoa-based CSF biomarker for C9orf72FTD/ALS great collaboration with FTDtalk GENFI Jon Rohrer Wave Life Sciences Dr Amanda led by Katie Wilson and Eszter Katona medrxiv.org/content/10.110…

Just a handful of tickets left for the Dementia Demystified event in London next week - grab one while you can! UK Dementia Research Institute The Francis Crick Institute CZI Science eventbrite.co.uk/e/dementia-dem…

Amazing time at the The Francis Crick Institute speaking at #DementiaDemystified. Great job Team Purple !

Synaptic world, the Volynski Lab strikes back! Using iGluSnFR,we just showed how release timing and synaptic efficacy are intimately linked at small synapses! So happy to share this with my dear sniffer companion Philipe Mendonca and my former PhD student Helen Langley!

Waiting for you at #IoNSeminarSeries UCL Queen Square Institute of Neurology

Our new preprint identifies genome wide the RNAs bound by C9orf72 polyPR a great collaboration with ule_lab and ShorterLab led by Rubika Balendra UK Dementia Research Institute biorxiv.org/content/10.110…

Transcriptome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides, delighted for this work with Adrian Isaacs, Rubika Balendra, PataniLab, ule_lab et al. to be out in LifeScienceAlliance! life-science-alliance.org/content/6/9/e2…

Check out our new preprint on generation and characterisation of C9orf72 polyGR and polyPR knock-in mice. A huge effort over many years by Carmelo Milioto and many collaborators incl. Marc Aurel Busche Soyon Hong biorxiv.org/cgi/content/sh… 1/5

Today the UK approved a gene therapy to treat sickle cell disease and thalassemia. It’s the first treatment ever to be licensed using the gene editing tool Crispr and will have huge implications for people living with these conditions. bbc.co.uk/news/health-67…

Online now: Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development dlvr.it/T0lR1X

Cervello: quel legame tra cellule del sistema immunitario e aree deputate alla memoria corriere.it/salute/neurosc…

Alzheimer, così si indagano le cause nelle prime fasi di vita - la Repubblica repubblica.it/salute/dossier…

Really excited about our latest preprint, where we uncovered a neuroprotective role for neuronal polyunsaturated fatty acids in FTD and ALS. Led by Ashling Giblin and Alex Cammack biorxiv.org/cgi/content/sh… 1/9

Delighted to see our study led by Carmelo Milioto revealing a neuroprotective ECM signature in C9FTD/ALS published! Thanks to MND Association UK Dementia Research Institute and many others! nature.com/articles/s4159…

A new study led by Prof Adrian Isaacs Adrian Isaacs (UCL Queen Square Institute of Neurology & UK Dementia Research Institute) provides fresh insight into early changes that occur in the brains of people with #ALS & #FTD, and reveals a response in cells that protects against neurodegeneration. Read more ⬇️bit.ly/3TmhQiF

This year, research by Adrian Isaacs Lab revealed insight into early changes that occur in the brains of people with ALS. Using a mouse model, the team unexpectedly uncovered a protective response in neurons that could be harnessed for new treatments 👉buff.ly/3V5EZHc 2/6

Today is an happy day! Carmelo Milioto from Università degli Studi di Milano and Arianna Manini from Istituto Auxologico Italiano and both former UCL Queen Square Institute of Neurology, are the two youngest recipients of 2024 Fondazione AriSLA Pilot Grant!

#convegnoarisla AriSLA annuncia nuovo finanziamento di 840mila€ per supportare 9 progetti di ricerca #BandoAriSLA2024, che coinvolgeranno 15 gruppi di ricerca distribuiti in sette regioni diverse -> Scopri di più arisla.org/bando-arisla-2…

#RareDiseaseDay Per la campagna #ricercaèvalore oggi condividiamo il contributo di Carmelo Milioto, ricercatore Università degli Studi di Milano e coordinatore del progetto 'SpiMNALS' supportato da AriSLA, con cui punta a sviluppare un nuovo modello di studio della #SLA. -> bit.ly/CarmeloMilioto