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We’re delighted to welcome Professor Jason Chin (@MRC_LMB) to WIMM Day 2024, where he is delivering the 10th Weatherall Lecture on “Reprogramming the Genetic Code”.

Calling any UK-based Canadian researchers... I'm organising a meeting at Canada House in July and we're looking for participants in the area of biomedicine who are keen to build academic:industry relationships across Canada and UK. Get in touch!

We say goodbye to Joe Cross and Ling R who both return to clinical haematology training next week. You will be missed in the lab ☹️; all the very best!

NEW preprint from Hughes Group & Watkins labs:

Focal deletions of noncoding regions in cancer genomes can have unexpected consequences. Out now in Blood Journal, we’ve discovered an intriguing mechanism of oncogene activation whereby focal deletion of a ‘promoter tether’ leads to aberrant expression of IRX3 in T-ALL. Thread👇

💫NEW: Combining degron-based depletion with live-cell transcription #imaging and single-particle tracking, Rob Klose, Aleksander Szczurek & co show that #Polycomb keeps promoters in an OFF state by restricting the formation of the pre-initiation complex. nature.com/articles/s4155…

Cost of having DNA methylation: DNA replication by DNA polymerase epsilon is a source of C to T mutations in CpGs, especially methylated ones. This expands our understanding of one of the most widespread endogenous mutational mechanisms. nature.com/articles/s4158…

This is a really important new finding from Skirmantas Kriaucionis and team. I would urge everyone to read! Very carefully done and compelling.

Thrilled to see this work out Science Translational Medicine dissecting how MPN cancer cells reprogram their niche to fuel progression, and uncovering Galectin-1 as a targetable mediator science.org/doi/10.1126/sc…

Trying to unlock a generous donation from a University of York staff member… just need three donors from countries across the world to get there! Share with alumni and friends across the world to get that cash unlocked! spsr.me/unW5

Last few hours to help fund science-based students across Yorkshire. GenerationResearch is specifically designed to widen access to scientific careers... And it pays a fair wage while giving essential experience Help drive the change. Donate now: spsr.me/unW5

#ASO nuclear localisation unlocked via (+)-JQ1 conjugation! We’ve enhanced the splice switching activity and RNase H-recruitment of antisense oligonucleotides🧬 One of my main DPhil projects #RNAtherapeutics! Michael Booth Tom Milne Chemistry in Cells Oxford Chemistry MRC WIMM

Different patients can have unique enhancers driving gene expression in their leukemias: Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression between patients biorxiv.org/content/10.110…

Thrilled to share a wonderful collaboration with Scott Armstrong Florian Perner Shellaina Gordon !! Catalytic inhibition of KAT6/KAT7 enhances the efficacy and overcomes primary and acquired resistance to Menin inhibitors in MLL leukaemia biorxiv.org/content/10.110…

I am two days late with this, but congratulations to Vassi Sharlandjieva for successfully defending her thesis! And a big thanks to examiners Brian Huntly and andi roy ! MRC WIMM MRC MHU

Well done Ling R for presenting your DPhil project at OCH Day MRC WIMM Oxford Cancer Department of Paediatrics

Thrilled to share my 1st brainchild, out today in Nature Genetics ! Been hearing a lot about fetal-like states lately? Here, we uncover the molecular mechanisms, functional significance and clinical relevance of #oncofetal reprogramming in CRC. rdcu.be/d9iSN a 🧵

Delighted to share our work on clonal hematopoiesis #CH out now in Nature Genetics. We revealed ancestry as a risk factor for CH 🧵 AstraZenecaUK Cambridge University nature.com/articles/s4158…