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Publications in the past week built substantially on our knowledge of the brain's waste disposal system—glymphatics—and the implications on sleep and brain aging. Featuring exceptional work by NedergaardLab Maiken Nedergaard and Jonathan Kipnis 💔🎗️ Open-access; link below

Tetanus on demand! (not for bioweapons, but for neuroscience research) Tetanus toxin induces paralysis by using a protease to cleave VAMP2, a protein required for synaptic vesicle fusion and neurotransmitter release. To harness this toxicity and use it as a beneficial tool for

Our thymus, a critical source and trainer of T cells, involutes with aging. 2 new studies find a growth factor (FGF21) that delays involution (in mouse models) and may be a way to rejuvenate our immune system and promote healthy aging in the future. nature.com/articles/s4358…

🚨Paper alert 🚨 Our latest research is out in nature! We reveal a surprising new role for the proteasome in innate immunity: generating antimicrobial peptides that can directly disrupt bacterial membranes. 🦠⚡ Weizmann Institute Systems_Immunology_WIS 🔗 nature.com/articles/s4158… 🧵👇

Excited to share our work by exceptional postdoc, Kyungdeok (KD) Kim. 2025 marks 10th anniversary of meningeal lymphatic discovery and I can’t be happier celebrating it with this work addressing how lymphatic dysfunction leads to cognitive deficits || Meningeal

Boosting brain’s waste removal system improves memory in old mice – WashU Medicine medicine.washu.edu/news/boosting-…

Proud to share our latest Cell paper. We present a novel immune population termed PNS microglia that regulate neuronal soma size throughout evolution. cell.com/cell/abstract/… #Microglia#PNS#NeuronalSomaSize#Macrophage#BodySize#Neuroimmunology#Evolution (1/8)

Our news&views piece, masterfully written by Siling Du on this beautiful story by Hanjie Li and his lab, is here: nature.com/articles/s4142…

‼️BIG news ‼️ #ReThinkNeuroimmunology #RTN registration is open and live! The program is amazing! Hurry up to register while prices are low! See you in Boston in October! Kipnis Lab IdoAmitLab Fran Quintana Lab beth stevens Rejane Rua genelayinstitute.org/rtn/

Excited to visit NIH next week as NIH Director's series speaker! Looking forward to seeing many friends and discussing science with them! nihrecord.nih.gov/2025/04/25/kip…

Redefining CNS immune privilege bit.ly/432fwRC

Pleased to see our perspective with ⁦Leon Smyth⁩ now online || Redefining CNS immune privilege | Nature Reviews Immunology nature.com/articles/s4157…

Happy to share our work on hippocampal inflammasome signaling. Thank you to members of the lab for critical experimental support, BIG_UVA colleagues for input, and John Lukens for baller mentorship - it's been an honor working with you all! cell.com/immunity/fullt…

Excited to share our new work demonstrating a role for astrocytic inflammasome signaling in modulating hippocampal plasticity. All credit to Kristine Zengeler, who was the brains🧠 and muscle💪 behind this project and is a wonderful collaborator.

Excited to share the review by ⁦Mitchell (Min Woo) Kim⁩ on how brain washing is linked to Neuroimmunology || Glymphatics and meningeal lymphatics unlock the brain-immune code: Immunity cell.com/immunity/fullt…

Online now: Glymphatics and meningeal lymphatics unlock the brain-immune code dlvr.it/TKYG6J

The gylmphatics of our brain, which clear waste products, interact with our immune system and are key to preserving brain health, modulating its aging process, and propensity for neurodegenerative diseases A superb review Jonathan Kipnis 💔🎗️ Immunity cell.com/immunity/fullt…

Check out our special collection on #neuroimmunology that is online now! cell.com/immuni/newarti… #AAI2025

The brain & immune system are more connected than ever imagined. In this issue of Immunity, 9 articles explore major advances & future directions in neuroimmunology. Take a look! hubs.li/Q03lzQ3H0

What a beautiful cover of Immunity ! Thank you Ella Marushchenko and team and bravo Mitchell (Min Woo) Kim for the idea! ❤️👍🤩