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Excited to share our preprint “Noradrenergic tuning of arousal is coupled to coordinated movements” from mbruchas' lab. biorxiv.org/content/10.110… How does an animal coordinate arousal and movement?

Wondering whether insight is more likely after sleep? Check out our pre-print and Anikas summary below. That was fun Anika Löwe & Nico Schuck & twitterless Maria Tzegka!

Happy to share Nina Engels (Domínguez) work: #locuscoeruleus integrity predicts elevated entorhinal tau better than amyloid-PET or hippocampal volume in asymptomatic older persons. Low LC integrity was associated with a 2-fold risk of clinical progression @MGH_RI 🔵 onlinelibrary.wiley.com/doi/10.1002/an…

Very pleased to share our first experiments looking at how norepinephrine controls the segmentation of episodic memory biorxiv.org/content/10.110…

So excited 🤩 … in 'stealth mode' > 6 yr We combine SWIR imaging & data analysis for touchless continuous tracking of human #gaze direction & #pupil size in CLOSED EYES Paper 👇validates technology; next: towards clinical use #ICU #anesthesia #sleep rdcu.be/dP6QA

New preprint with @LilaDavachi and Ringo Huang! Ever wonder how your brain knows when one memory ends and another begins? We show that the locus coeruleus acts like a ‘reset’ button for memory when things change💥🔵 biorxiv.org/cgi/content/sh…

Our second living Bayesian meta-analysis on tVNS-induced effects is online now 👀. In this preprint+app, we analyze pupil dilation and find marked differences between pulsed (works!) vs. continuous protocols. biorxiv.org/content/10.110…

Pupil self-regulation modulates markers of cortical excitability and cortical arousal biorxiv.org/cgi/content/sh… #biorxiv_neursci

🔔🔵After nearly 5 years from its conception with Johannes Bohacek, I'm proud to share that our paper on opto-fMRI of the Locus Coeruleus is finally published in Nature Neuroscience! Huge thanks to everyone who contributed—including reviewers and editors! rdcu.be/dT3kB

Our toolbox paper is finally out.

To advance the study of coma & consciousness, we created a FreeSurfer algorithm that automatically identifies brainstem nuclei in MRI scans. preprint:medrxiv.org/content/10.110… code:surfer.nmr.mgh.harvard.edu/fswiki/AANSegm… Mark Olchanyi Juan Eugenio Iglesias MGH Martinos Center @MGH_RI MGH Center for Neurotechnology and Neurorecovery MIT IMES

Integrating brainstem and cortical functional architectures | nature.com/articles/s4159… led by Justine Hansen in Nature Neuroscience 400 cortical regions + 58 brainstem nuclei. Lesgo 🤘🕶️⤵️

Attention all LC lovers, this is a pre-print you won't want to skip! We combined over 1800 single unit LC recordings across 20 labs to ask whether LC firing is different across various conditions biorxiv.org/content/10.110…

Using multimodal structural and functional neuroimaging approaches, Wiesman et al. show that in Parkinson's disease, alterations in alpha and beta brain rhythms are related to degeneration of the noradrenergic and dopaminergic systems respectively. tinyurl.com/28nfau8f

Longitudinal neuromelanin changes in prodromal and early Parkinson's disease in humans and rat model biorxiv.org/cgi/content/sh… #biorxiv_neursci

We have starting developing a *programming first* self-study pipeline to understand the fMRI signal in OHBM 2024 Brainhack. Might be useful for those who learn by interacting with the equations. A summary of the project can be found at: youtu.be/jQyK0ZV1LzY

How does sleep deprivation contribute to #AlzheimersDisease ? Our new paper in Cell Reports shows that disrupted norepinephrine signaling after sleep loss slows protein clearance and alters CSF/ECF #proteome, increasing risk for #Alzheimers University of Copenhagen Research cell.com/cell-reports/f…

Excited to share our review, w. shany grossman (shared 1st!) and Nico Schuck where we discuss representational spaces in OFC/vmPFC and in deep RL models, featuring values, states and much more! cell.com/trends/neurosc…. Fresh from the (virtual) print now in Trends in Neurosciences , 1/4

SleepLüthiLab uncovers a dual role of #locus Pierre-Hervé Luppi in #sleep -> 1) its strict gatekeeper role for the sleep cycle 2) the partial brain-body arousals it generates. Powerful minds behind all this: Alejandro Osorio-Forero Georgios Foustoukos Romain Cardis nature.com/articles/s4159…

Neuromodulatory Subcortical Systems PIA's YIR always offers valuable insights into clinical and preclinical studies. Join YIR to explore last year's NSS findings. We warmly welcome all enthusiastic AD researchers to join PIA. Stay updated on research into subcortical regions where early tau pathology begins.