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Excited to share out labs’ latest: Congrats to Reagan Pennock, Luke Coddington, Xiaohiu Yan, Linda Overstreet-Wadiche & Jacques Wadiche. 'Afferent convergence to a shared population of interneuron AMPA receptors' (2023) Nat Comm. go.nature.com/42iT6ZX. A thread:

Congrats to the Soden and Zweifel labs for getting this out! Really remarkable use of CRISPR and neurophysiology! Circuit coordination of opposing neuropeptide and neurotransmitter signals nature.com/articles/s4158…

I was excited to give a lab tour this week to Oklahoma County Commissioner and mental health advocate Commissioner Carrie Blumert. We had a nice chat about brain research and the challenges of studying addiction.

I’m guessing we were the only people that saw the Guardians win today that drove straight from Oklahoma. First big league game for the kids, and we got a foul ball — they were so excited (so was I)!

Congrats to Will Lynch @wil1l_obie who just received his NOA for his F31 award on the role of Zhx2 in oxycodone metabolism and behavior! Center for Systems Neuroscience, Boston University Boston University Genome Science Institute Boston U Chobanian & Avedisian School of Medicine BU Pharmacology💊 BU Neuroscience 🧠 I.B.A.N.G.S IBNS Complex Trait Community CPDA Conference 2017

Shades of post-1989 USSR in the US since the GFC in 2008. Comparable countries bounced post-COVID, but US did not. ~1 million Americans have died of OD’s just since 2010; that’s more than the # of Americans that died in all wars America has ever fought in. Via Dan DiMicco

Hyperexcitable VTA dopamine neurons in an AD mouse model?! Check out our latest preprint where we use Patch-seq to ID a single enzyme & target it to restore normal firing. Work led by PhD student Harris Blankenship; big shouts to SharpeLab Freeman Lab doi.org/10.1101/2023.1…

Lots of traveling this fall - fun but glad to be home for a while. Date night Friday, spectacular overtime win for the Thunder over the Warriors!

I am so excited about stepping into this new role as Director of Vanderbilt Center For Addiction Research. Vanderbilt University, Vanderbilt School of Medicine Basic Sciences and the addiction center have been so supportive of my career and I can’t wait to give back to the Vanderbilt community in this role.

Delighted to share our latest work using ChR2 in LC to evoke noradrenaline alpha1-adrenergic receptor synaptic transmission in the dorsal raphe - which is exquisitely sensitive to presynaptic inhibition. Amazing team effort 🙏🏽 nature.com/articles/s4138…

The lab's first paper is published! Post-doc Rita Yu-Tzu Chen used two-photon dendritic calcium imaging to compare the role of specific calcium channels in two types of neurons that degenerate in Parkinson's Disease. onlinelibrary.wiley.com/doi/full/10.11…

What a great trip to Iowa to talk about our Alzheimer’s work and see the cutting edge science going on here. Thanks to the graduate students, faculty, and Stephanie Gantz for an amazing visit!

I, Ana Luiza Bock, and Laci Liter from my lab all ran legs to help represent OMRF in the OKC Memorial Marathon relay this morning! We had a bit of drizzle but the weather was great for running. So much fun! #runtoremember

Exciting news from our lab at Duke University! We've used DART to block dopamine pauses mediated by GABAA receptors. This simple experiment led to three unexpected outcomes. See more in our full paper: tinyurl.com/5x99phdd Duke Biomedical Engineering Duke Institute for Brain Sciences Aligning Science Across Parkinson’s #ASAP_CRN

Patched locus coeruleus norepinephrine neurons all morning and ventricular cardiomyocytes all afternoon.

Great week at #SfN24. I learned a ton but the highlight for me was watching Harris Blankenship represent our lab by presenting his Alzheimer's (and dissertation) work -- great job! Aging and Metabolism Research Program

Can we design allosteric modulators that change a GPCR's preferred G protein? Yes!💥 BAMs at the GPCR-transducer interface change G protein subtype selectivity in predictable ways, enabling rational drug design. The lab's 1st preprint! Check it out! doi.org/10.1101/2024.1… 🧵👇

A neurotensin-dependent neural circuit mechanism that links the devaluation of hedonic foods with #obesity nature.com/articles/s4158…

Woohoo! Great job Laci!