A trend we've been seeing in recent de novo protein backbone design is the overrepresentation of alpha helices, compared to very few topologies with beta sheets. Thanks to the resource below, we can see that this has actually been ongoing for decades now

Ever wish there was a way to easily browse designed proteins? You're in luck! Introducing the Protein Design Archive - your go-to resource for exploring designed protein structures across the last 40 years! Website: pragmaticproteindesign.bio.ed.ac.uk/pda/ Preprint: biorxiv.org/content/10.110…

Just putting some papers on the timeline:) Looking forward to seeing if we are now in the fourth phase (with deep-learning adding even more designs per year). Also nice to put some numbers onto things people have long suspected (like overrepresentation of alpha helices).

#333: Ft. Elm Town & 🦋 hayleigh.dev, Christopher W. Wood & Michael Stam & Marta Chronowska & WoolfsonLab, Nelson Correia, and Cλris. elmweekly.nl/p/elm-weekly-i… #elmlang

There is a new tool on BioIcons to turn any protein (in PDB format) into a 2D vector illustration in SVG format. You can upload any PDB file or import from PDB, AlphaFoldDB or ESMFoldDB. Feedback welcome :) bioicons.com/pdb2vector/

🚀 Protein Design Competition: Design phase completed -> Wet lab validation started We’ve received well over 1000 protein designs by 130 amazing proteins designers for the 2nd round of our competition. With so many people enthusiastic about designing novel proteins and so many

So proud of my lab members applying all our tools to design EGFR binders for the Adaptyv Bio competition. Their designs are currently ranked 30/1000+ from the computational analysis, 🤞 for the binding assay results! Thanks for running the competition Adaptyv Bio! #proteindesign

Excited to announce that our team's designs ranked among the top 30-57 positions in the Adaptyv Bio protein design competition, distinguishing themselves among over 1,000 submissions! So proud of our team! 😀

PROTEIN DESIGN COMPETITION ROUND 2 The long awaited results are here -- and they don’t disappoint! 📈 We doubled the number of proteins we tested in our lab from 200 to 400! 🧬 Out of those 400 proteins, 378 expressed (95% expression rate!) 🚀 Out of those 378 expressed

🎇 We're kicking 2025 off with a Protein Design Archive update, adding structures such as miniaturized electron-transfer proteins, small molecule and protein binders, beta barrels and hairpins, oligomers, and more! Check out all of them at pragmaticproteindesign.bio.ed.ac.uk/pda/ Christopher W. Wood

Our paper on computational design of chemically induced protein interactions is out in nature. Big thanks to all co-authors, especially Anthony Marchand, Stephen Buckley and Bruno Correia nature.com/articles/s4158…

A framework for evaluating how well generative models of protein structure match the distribution of natural structures. Possu Huang Lab

Our paper on the Protein Design Archive has just been published in Nature Biotechnology! It describes our web application for exploring designed proteins (link ⬇️) and contains analysis of how they have changed over time. Marta Chronowska Michael Stam WoolfsonLab nature.com/articles/s4158…

The Protein Design Archive (PDA): insights from 40 years of protein design go.nature.com/4iNRFLI

Introducing BenchBB and the community paper of the Protein Design Competition 🎉 We wrote a community paper about our Protein Design Competition, teaming up with your favourite protein designers from both rounds. Excited to announce that this is now on Biorxiv 🙌

We're delighted to announce that our conference "Protein Evolution, Design and Informatics Edinburgh 2026" will be running from the 13th-15th of May. Register interest here and please retweet! biochemistry.org/events-and-tra…