THREE methods to detect SARS-CoV-2 variants in wastewater 1. Freyja nature rdcu.be/cR7A8 Knight Lab ) 2. COJAC ( Nature Microbiology Tanja Stadler CBG, ETH Zurich rdcu.be/cR7Cd) 3. VaQuERo Nature Biotechnology The Bergthaler Lab rdcu.be/cR7Dn)

A metagenomic DNA sequencing assay that is robust against environmental DNA contamination nature.com/articles/s4146…

Our take on how to use alphafold to design peptide binders. In contrast to other work we do bout require that the structure of the peptide or the target is known, all you need is a list of binding residues at the target. biorxiv.org/content/10.110…

Li, Wei & co develop an enhanced prime editing 2 system for plants. They combine optimization approaches such as expressing engineered pegRNA with a structured motif from a composite promoter, to achieve editing efficiency of up to 77% in rice genomebiology.biomedcentral.com/articles/10.11…

Nanocarriers based on bacterial membrane materials for cancer vaccine delivery nature.com/articles/s4159…

New Bahlo Lab paper RE detection tool paper describing SuperSTR. Led by Liam Fearnley, with Mark Bennett: Detection of repeat expansions in large next generation DNA and RNA sequencing data without alignment disq.us/t/49jjti2 Hope you find it useful!

"Enhancing glycosylase base-editor activity by fusion to transactivation modules" Dong X, Yang C [..] Chen M, Zhang X, Bi C. Cell Rep 2022-07-19. doi.org/10.1016/j.celr… #CRISPR Vp64-GBE, SpCas9 > SpRY

Sensbio: An online server for biosensor design biorxiv.org/cgi/content/sh… #bioRxiv

Design of ultrasound-responsive bacteria for the controlled release of IFNγ : implications for cancer immunotherapy. nature.com/articles/s4146… #CancerResearch @natrescancer

Happy to share our new Nature Nanotechnology paper on nanozyme powered #CRISPR diagnostics for RNA detection. Great teamwork w Marta Broto, Adrianus Christopher and the labs of of Molly Stevens Bioengineering and Jim Collins MIT Dept of BE. Brief thread 👇 (1/4) nature.com/articles/s4156…

CASPER: An Integrated Software Platform for Rapid Development of CRISPR Tools Mendoza et al. liebertpub.com/doi/10.1089/cr…

REVIEW: Recent Advances in CRISPR-Based Biosensors for Point-of-Care Pathogen Detection Mohammad et al. liebertpub.com/doi/10.1089/cr…

A graphics toolkit for visualizing genome data. #GenomeData #VisualizationTools nature #TechnologyFeature nature.com/articles/d4158…

Our #github collection of #bioinformatics #training material has now >110 repos. All free to (re)use! My favorites? ‘Art from code’ by Danielle Navarro and ‘Analysis of single cell RNA-seq data’ by Martin Hemberg et al. Course missing? Write an issue or PR! bit.ly/3KdmEkb SIB

The Australian AlphaFold Service is now available to all Australian researchers! Easy to use, backed by powerful resources, no cost to researchers thanks to Galaxy Australia Learn more about how local life scientists are using it and apply for access: biocommons.org.au/news/alphafold

R Programming for Beginners | Complete Tutorial | R & RStudio youtu.be/BvKETZ6kr9Q via YouTube #rstats #rstudio

"Improved Genome Editing by an Engineered #CRISPR-Cas12a" Ma E, Chen K [..] Doudna JA. bioRxiv 2022-09-02. doi.org/10.1101/2022.0… structure-guided design + directed evolution + site-specific reversion mutation = iCas12a

Today we report in Nature Biomedical Engineering the eePASSIGE system, which uses evolved and engineered recombinases and prime editing to integrate large gene-sized DNA cargoes into the mammalian genome in an efficient, precise, and targeted manner. (1/13) drive.google.com/file/d/1WDMVqL…

Many new machine learning tools for protein engineering have popped up in the last year. In these early days, it might be unclear how to actually use them for real molecular design tasks in industry. We demonstrate how to engineer a cholesterol drug and plastic degrading