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#HighFatDiet ameliorates mitochondrial #cardiomyopathy in #CHCHD10 mutant mice. By N. Southwell, H. Kawamata & colleagues Weill Cornell Medicine ➡️doi.org/10.1038/s44321… Read also related News & Views by H.P. Lin & D. Narendra NINDS ➡️doi.org/10.1038/s44321…

Excited to announce the launch of our new research lab website! 🌐🔬 Discover our latest projects, publications, and team. Visit us at mmittelbrunnlab.cbm.uam.es and explore our work! #Immunity #Aging #Research #Longevity #Tcells

#NatMetabPicks | In Nature Aging led by T. Minamino (Juntendo University): SGLT2 inhibition reduces senescence and alleviates #aging traits in mice 🐭💊. Senescent cells are removed indirectly through enhanced immunosurveillance. nature.com/articles/s4358…

So thankful to receive the best oral presentation award in the Oral-Gut Conferences conference at Karolinska Institutet 🇸🇪 Top-class speakers and cutting-edge research in such a beautiful city. Keep your mouth and gut healthy! #OralGut2 Mittelbrunn Lab

Happy to share a comprehensive protocol to unbiasedly analyze the whole murine #gastrointestinal tract at once! Published in Nature Protocols Link: rdcu.be/dLwhG @Papervids 👇🏻 youtu.be/F65gaGdKMus?fe…

Impressive study showing that inhibiting interleukin-11, a pro-inflammatory cytokine, extends lifespan in mice by 25%. Both genetic deletion and an anti-IL-11 drug worked, and it's exciting that anti-IL-11 therapies are already in human clinical trials. nature.com/articles/s4158…

Nucleophosmin 1 promotes mucosal immunity by supporting mitochondrial oxidative phosphorylation and ILC3 activity nature.com/articles/s4159…

Online now! Mitochondrial transplants to treat mitochondrial dysfunction dlvr.it/TCjPm9

Very well-deserved, Carlos! 🙌🏼🥳🥂 Looking forward to seeing the upcoming advances in the field of senescence and aging 👴🏼🧓🏼

New Research: The 3 I’s of immunity and aging: immunosenescence, inflammaging, and immune resilience frontiersin.org/articles/10.33… #FrontiersIn #Aging

Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging cell.com/cell/abstract/…

💫 Check our new review article on #cancer #cachexia Nature Metabolism in which we focus on describing the multi-layered nature of this complex metabolic disorder. Link below 👇

REVIEW: Harnessing the biology of regulatory T cells to treat disease nature.com/articles/s4157… Nature Reviews Drug Discovery Megan Levings Christine Wardell

Aging-related increase in #GutMicrobiota-derived phenylacetylglutamine accelerates host cellular senescence via DNA damage & mitochondrial dysfunction through adrenoreceptor-AMPK signalling #aging #GutMicrobiome Nature Aging nature.com/articles/s4358…

Happy to share our recent work led by postdoc Dan Corral showing that the maternal adapative immune system promotes optimal lactogenesis. cell.com/cell/abstract/…

We are glad to present our exploration of aging, dietary restriction, genetics, and the microbiome, led by levlitichev, together with our collaborators The Jackson Laboratory and Calico, just published at Nature Microbiology. Major findings are the following: (1/8) nature.com/articles/s4156…

KLRG1 identifies regulatory T cells with mitochondrial alterations that accumulate with aging Nature Aging nature.com/articles/s4358… Mittelbrunn Lab Gonzalo Soto-Heredero

Finally out! Interested in age-related CD4⁺ T cell alterations? Check our latest Nature Aging paper Mittelbrunn Lab nature.com/articles/s4358… Thanks to the amazing colleagues who made this possible! Enrique Gabandé Rodríguez Isaac Francos Quijorna Elisa Carrasco Manuel M. Gómez de las Heras Nacho Escrig Larena Centro de Biología Molecular Severo Ochoa CSIC

Online now! Soto-Heredero et al. show that Tregs characterized by the expression of KLRG1 accumulate with age in both mice and humans, and exhibit features like mitochondrial decline and an inflammatory phenotype. doi.org/10.1038/s43587…

🚨Just published in ⁦⁦Nature Aging⁩! 🧬 We discovered that a gut #microbiota-derived metabolite, phenylacetic acid (PAA), accumulates with age and triggers endothelial #senescence, a key driver of cardiovascular #aging. #Saeedi_Lab ➡️ Read more nature.com/articles/s4358…