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🔬New insights on bacterial histones! 🧬 Our study, led by Yimin Hu & @SammyBoterhammy, shows that in Bdellovibrio bacteriovorus, HBb bends DNA uniquely, differently from eukaryotic & archaeal histones. Great collaboration with Birte Hernandez, Remus T. Dame. @MPIBio LeidenScience ENG

Delving deeper, we used DAP-seq to reveal that HBb binds along the entire genomic DNA of B. bacteriovorus without sequence specificity. The wonders of bacterial histones continue to unfold! Dive into our manuscript for more details: 👉 biorxiv.org/content/10.110…

We are hiring! Calling all outstanding candidates in the field of intelligent systems to establish up to two new W2 independent #research groups at our institute's #Stuttgart site: #Robotics, Human-Machine Interaction, Robotics for #Healthcare, #AI etc. is.mpg.de/jobs/research-…

For those of you who missed this post last year, I welcome applications until the end of January. This is approximately 50% bench and 50% computation, involving both microbiology and plant work.

We have a new story out at BiorXiv! Amazing work led by Zachary Curtis (Bisson), Pedro Escudeiro (Alva) and John Mallon (Bisson). Great collaboration with Vikram Alva (Max Planck) and Mechthild Pohlschroder (UPenn). A summary of our findings in the thread (1/22) shorturl.at/fLPR1

Thrilled to share our latest preprint on BiorXiv! A fantastic team effort led by Zachary Curtis, Pedro Escudeiro, and John Mallon! Check out Alex Bisson's thread for a quick dive into our exciting findings! 🔬

Did you know that sex determination in brown algae and animals shares a fascinating connection? 🌊 Our latest study reveals how HMG-box genes independently drive male sex determination in these distant organisms. 🧬 Take a deeper dive into the paper here: doi.org/10.1126/scienc…

🌱 Thrilled to share our latest research on #BrownAlgae sex determination! Led by Susana Coelho, our team has revealed a fascinating connection between the sex determination processes in brown algae and animals. #Evolution @MPI_Bio science.org/doi/10.1126/sc…

🔬Excited to share the revised version of our manuscript on the bacterial histone HBb from Bdellovibrio, led by Yimin Hu and @SammyBoterhammy. A fantastic collaboration with Birte Hernandez Alvarez, Remus T. Dame, Marcus Hartmann. @MPI_Bio LeidenScience ENG biorxiv.org/content/10.110…

Happy to share our review on the versatile and emerging roles of PII-like proteins in cell signaling, coordinating vital metabolic states across life forms. @MPI_Bio

I am excited to share our new preprint on the structure of S-layers. The work is a collaboration between Oxford Chemistry (Ed Johnston and myself) and Buse Isbilir and @TBharat_lab at @MRC_LMB and Vikram Alva at @MPI_Bio. 🧵 1/11 biorxiv.org/content/10.110…

Excited to share our new preprint on S-layers! We've modeled ~150 S-layers spanning the prokaryotic tree of life. Great collaboration with Ed Johnston, Jonathan Doye at Oxford Chemistry, Buse Isbilir, @TBharat_lab at @MRC_LMB, and myself at @MPI_Bio.

Some bacteria have proteins much like ours that organise their DNA. Biochemists from Remus T. Dame & the @MPI_Bio reveal this in a new paper. Their work helps us better understand evolution & how bacteria organise their DNA. Read: universiteitleiden.nl/en/news/2024/0… Vikram Alva @SammyBoterhammy

Thrilled to share our manuscript on bacterial histone HBb from Bdellovibrio in Nucleic Acids Res! We report DNA-bound HBb structures, showing its DNA bending properties. With Birte Hernandez Alvarez, Remus T. Dame, Yimin Hu, @SammyBoterhammy, @MPI_Bio, Leiden Science academic.oup.com/nar/advance-ar…

I am very pleased to share our recent study on prokaryotic histone structure and diversity nature.com/articles/s4146… Great work by PhD student @SammyBoterhammy. With Aimee Boyle, Vikram Alva, Birte Hernandez Alvarez, Yimin Hu, @MPI_Bio, Leiden Science

New paper online PNASNews! Great collab with Vikram Alva, Pohlschroder Lab, Amy Schmid and inspiring team work within the Bisson lab. PNAS: shorturl.at/tzNqn Preprint: shorturl.at/Wi58N Blurb: shorturl.at/vMZsZ highlights below (1/4)

This story started 5y ago with my lab. Spearheaded by fearless 1st authors theopi and Olivia Leland. Theopi is now a PhD student at Brown University. Olivia is a physics PhD student at Brandeis University, a self-taught biologist, and made us love soft matter. A (very long) thread (1/24)

Excited to share our team's discovery on tissue-like multicellularity in archaea under mechanical compression! Led by theopi, Olivia Leland & Alex Bisson, it rethinks the evolution of multicellularity beyond eukaryotes. HFSP @MPI_Bio biorxiv.org/cgi/content/sh…

Donor Strand Complementation and Calcium Ion Coordination Drive the Chaperone-free Polymerization of Archaeal Cannulae biorxiv.org/content/10.110… Happy that the preprint is now published. Great collaboration with fantastic colleagues. conticellolab Emory Chemistry