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Look, Ma, no B-factors! Great working with Ann Jain Alex Brueckner @edsherer Mikhail Reibarkh Chip Lesburg #xGen

Thank you Girl Scout Service Unit 48 for presenting the colors tonight. Good luck Cougars!

Come join the Molecular & Materials Characterization team! We are seeking motivated solid-state chemists or materials scientists with technical expertise in crystallization of small molecules, peptides, proteins & mAbs. #MerckChemistry #chemjobs jobs.merck.com/us/en/job/R802…

jobs.merck.com/us/en/job/R843…

jobs.merck.com/us/en/job/R843…

What a thread! Dono

Interested in an industrial postdoc where you can learn about catalysis, photochemistry and high throughput experimentation? See here for an exciting opportunity at Merck (catalysis group - Rahway, NJ): here: jobs.merck.com/us/en/job/R857…

Interested in a career in chemistry at our MSD London site? Check out this virtual event. It's free to register with the link below. Come and learn more! Dixon Group is also presenting a seminar. #MSDChemistry #MerckChemistry merck.webex.com/merck/onstage/…

Join our NMR team!

I made a (hopefully) useful demonstration of the effect field strength has on chemical shift, coupling constants and resolution. The resonant frequency and coupling constant for the doublet (far right) are shown in ppm and Hz. Figured #chemtwitter was a good place to share this

Gareth Morris won the Laukien Prize this year for the profound impact this work had on modern magnetic resonance. In our department alone we run thousands of INEPT based experiments every year. -LE

Tell it like it is, man!

Know the difference! Some common schools of pulse sequence diagrams in NMR:

Proud of our surprising results! Great working with Ann Jain @edsherer Alex Brueckner and Mikhail Reibarkh again: A Distributional Model of Bound Ligand Conformational Strain: From Small Molecules up to Large Peptidic Macrocycles pubs.acs.org/doi/10.1021/ac…

. Nature Communications (open) Identification of two-bond heteronuclear correlations in natural products at nanomole scale by i-HMBC, corresponding Mikhail Reibarkh Mikhail Reibarkh and Xiao Wang, Merck, Rahway, NJ nature.com/articles/s4146… #NMRchat #NMR

Summary: bond multiplicity information is contained in the HMBC data, and one can extract this information via isotope shifts. Xiao Wang and the team did a fantastic job. @edsherer

Wild-type transaminases, a lysine smart donor, and a great scope of noncanonical amino acids, out today in J. Am. Chem. Soc. (pubs.acs.org/doi/10.1021/ja…). All thanks to a crack team! Steven Silverman, Matt Winston, RITWIKA RAY, Yining, Mikhail Reibarkh

Yes, you can use flow-NMR for large molecules with complex behavior: case study of liraglutide oligomerization | Analytical Chemistry Jim Xu, Yining, #MerckChemistry pubs.acs.org/doi/10.1021/ac…