Bryan Carmody Don’t you think this is going to make WHERE you graduate medical school have much more influence after Step 1 pass/fail?

I’m trying to interpret this hotel sign. The closest I can get is “don’t hide in a hanging box if C. elegans are attacking you”.

I think most people aren’t aware of the risk of systemic healthcare failure due to #COVID19 because they simply haven’t run the numbers yet. Let’s talk math. 1/n

The New York Times Same issue, Similar measures, Quite OPPOSITE comments from NYT! What better words than “double standards “?

Nicely formatted COVID-19 data aggregated from each state

So cool!

"Everything we do before a pandemic will seem alarmist. Everything we do after will seem inadequate." - Michael Leavitt, former HHS Secretary under President George W. Bush

I used to think there were 2 types of scientist: -Those who naturally had heaps of great ideas for new projects -Those who didn’t have that ability. I ‘knew’ I was the 2nd type & would never be a great scientist because of it. Ever felt the same? Read on 🧵#phdchat

Was afraid of this

Lots of lucky folks are getting news about admission into grad school. Choosing the right mentor/ program can be a difficult but very important decision. Trust your intuition but get more info if needed; kindness is not sufficient but is necessary to be a good mentor. Good luck!

HHMI News: We are proud to announce our 33 new #HHMIInvestigators. These individuals have the potential to make transformative discoveries over time and we look forward to seeing where their ideas lead them. bit.ly/3AE4OBs

Going from GFP to EnhancedGFP made fluorescent reporters much more useful. Excited to take a similar step with second-generation Acoustic Reporter Genes based on #gasvesicles. Congrats to Mengtong (Tom) Duan, Marjorie Buss, Rob Hurt et al on this updated preprint. biorxiv.org/content/10.110…

If light scattering in tissue is causing issues in your research, perhaps it's time to consider acoustic reporter genes (ARGs). Mikhail Shapiro (same on bsky) 🇺🇦's lab shares the newest generation of bacterial and mammalian ARGs in our latest blog post. hubs.la/Q01y-Gr60

Can you express multiple genes from a single mRNA at programmable ratios without long intervening sequences or peptide overhangs? 🤔 Yes, with SEMPER! 😉 Congrats Mengtong (Tom) Duan, Ishaan Dev and coauthors on this new tech for mammalian synbio & gene therapy. biorxiv.org/content/10.110…

Thanks Nature Biotechnology for highlighting our work on this month's cover! Congrats to Rob Hurt, Marjorie Buss, Mengtong (Tom) Duan and colleagues, and the talented Maayan Harel 🟣 Visual storytelling for science who created the artwork. nature.com/articles/s4158…

The series of events leading from vesicle tethering to assembly of pre-fusion SNARE complexes is poorly understood. Duan, Merz and coworkers University of Washington discovered a latent, short-range tethering activity in the essential SNARE chaperone Sly1 hubs.la/Q02pljJx0 #Trafficking

SM proteins are essential SNARE cofactors for membrane fusion. The ER–Golgi SM, Sly1, has several different activities reported to promote fusion. Here, Duan, Merz et al University of Washington test each function in parallel genetic and biochemical reconstitution experiments. hubs.la/Q02plnQy0

SEMPER out at Cell Systems! 📜 What is SEMPER? A way to tunably co-express multiple genes from the same mammamlian mRNA. The final paper adds a model & expr. of a two-chain antibody w/heavy-light tuning. Congrats Mengtong (Tom) Duan, Ishaan Dev and colleagues! sciencedirect.com/science/articl…