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New preprint from the lab: Deep indel mutagenesis reveals the impact of insertions and deletions on protein stability and function. First paper from Magda with @ToniBeltran13 biorxiv.org/content/10.110…

Excited to finally share some of my PhD work on quantifying the effects of indel mutations on protein stability and function using deep mutational scanning. From sunny Centre for Genomic Regulation (CRG) together with @ToniBeltran13 and guidance from Ben Lehner biorxiv.org/content/10.110…

Excited to share a new, MUCH IMPROVED version of our deep indel mutagenesis (DIM) manuscript: biorxiv.org/content/10.110… See the thread below for details.

Excited to share Taraneh's preprint: A complete map of specificity encoding for a partially fuzzy protein interaction biorxiv.org/content/10.110…

Very happy to share what I've been working on in Barcelona with Ben Lehner ! We made many (>400k) mutations in a disordered peptide and the globular domain it interacts with to gain a comprehensive map of how specificity is encoded in a partially fuzzy protein interaction (1/n)

Thread by @ToniBeltran13 about the Src kinase allosteric map. And here is one view of the map. Centre for Genomic Regulation (CRG) Wellcome Sanger Institute

@ToniBeltran13 Centre for Genomic Regulation (CRG) Wellcome Sanger Institute That's the Src kinase domain alone. Here's the allosteric map of the kinase domain in the context of the full-length protein (+ SH2, SH3, SH4 etc).

The gut microbiome influences metabolites, hormones and immune function Perturbing gut microbiota therefore impacts homeostasis across somatic tissues Could it also affect the reproductive system - and even offspring? See our results👇& tweetorial🧵 rdcu.be/dGpoc

How do chromatin modifications quantitatively impact gene expression? How do sequence variants or combinatorial marks influence relationships? We developed a modular #EpigenomeEditing toolkit to systematically test these Q, published today 🧵… nature.com/articles/s4158…

Excited to share Albert Escobedo's randomisation of protein cores at scale: Genetics, energetics and allostery during a billion years of hydrophobic protein core evolution with Andre Faure @ajfaure.bsky.social Centre for Genomic Regulation (CRG) Wellcome Sanger Institute biorxiv.org/content/10.110…

The genetic architecture of protein stability by Andre Faure @ajfaure.bsky.social Aina Martí cristina hidalgo-carcedo @ToniBeltran13 Joern Schmiedel nature.com/articles/s4158… Centre for Genomic Regulation (CRG) Wellcome Sanger Institute ALLOX

📣 Two ERC-funded positions are available in the lab! If you’re interested in exploring the mechanisms underlying mutation, we’d love to hear from you. ibe.upf-csic.es/work-with-us/j… RTs and shares would be greatly appreciated!

Introducing Human Domainome v1, the largest and most comprehensive library of human protein variants to date, which maps the effects of +500K mutations across 522 domains. The study by Ben Lehner and Toni Beltran Toni Beltran is out in nature. ✍️ Illustration by Queralt Tolosa, PhD