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"Showcase your science, get inspired, and get new information" Mychael Lourenco, PhD, SfN Global Membership Committee member, shares how membership with SfN opens doors to opportunities at the annual meeting. #neurosky #academicchatter #neuroskyence

Alzheimer disease biomarkers are present in various dementia types, with the strongest correlations between cerebrospinal fluid biomarkers and cognitive function seen in patients with early and late onset Alzheimer disease. ja.ma/4jByJ2L

Pleased to see our latest paper published. The physiological role of the APP family has been sought since its first description more than 25y ago. We show the APP family is critical for spontaneous neuronal activity in the brain by regulating synaptic NMDA receptor function.

A plasma biomarker panel for detecting early amyloid-β accumulation and its changes in middle-aged cognitively unimpaired individuals at risk for Alzheimer’s disease thelancet.com/journals/ebiom…

Extremely happy that the review article on 'Neural metabolic networks' I contributed to as a part of Fourth International Society for Neurochemistry (ISN) and Journal of Neurochemistry (JNC) Flagship School held in Schmerlenbach, Germany (2022) is out now doi.org/10.1111/jnc.70…

Super happy to have contributed to this one! Made possible by an awesome South American collab led by Carlos Escande and Carlos Batthyány at Institut Pasteur Montevideo and Eduardo Chini at Mayo Clinic 🙌

Astrocytes have no CLU they contribute to Alzheimer’s disease: Neuron cell.com/neuron/fulltex…

O CAMPEÃO DA LIBERTADORES VENCE O CAMPEÃO DA CHAMPIONS! É BOTAFOGO DE FUTEBOL E REGATAS!

Neuroinflammation across neurological diseases science.org/doi/10.1126/sc…

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway: Immunity cell.com/immunity/fullt…

#preprint on Research Square from Cynthia Lemere's group: Global C3 lowering in adulthood protects against hippocampal dysfunction and cognitive impairment in aged mice researchsquare.com/article/rs-692…

Cytokine-induced reprogramming of human macrophages toward Alzheimer’s disease-relevant molecular and cellular phenotypes <em>in vitro</em> sciencedirect.com/science/articl…

Amyloid-beta accumulation in centenarians is associated with reduced cognitive performance and is not a benign aspect of aging. ja.ma/4lskuhU

Our featured article for August is this Review, in which Raquel Taddei and Karen Duff consider the importance and mechanisms of synapse resilience and vulnerability in dementia. You can read it in full for free here: rdcu.be/eurPp Duff Lab

Aerobic and resistance exercise-regulated phosphoproteome and acetylproteome modifications in human skeletal muscle nature.com/articles/s4146…

Optogenetic storage and release of protein and mRNA in live cells and animals Nature Communications nature.com/articles/s4146…

Pls spread the word! We have a postdoc position available in the Rocha Lab MPI Molecular Biomedicine. Join our team to study mechanisms underlying robust organ development using zebrafish embryos and human organoids. mpi-muenster.mpg.de/career

Early-life exercise extends healthspan but not lifespan in mice | Nature Communications nature.com/articles/s4146…

Most viewed this week from JAMA Neurology: Higher educational attainment is linked to slower tau accumulation in amyloid β-negative individuals but accelerates tau accumulation and spread in amyloid β-positive stages. #Alzheimer ja.ma/4kBVVOV

Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease nature.com/articles/s4159…