The Marr-Albus theory of cerebellar function has stood the test of time. A key element is “codon theory”: sparse granule cell activation facilitates pattern separation. However, recent experimental work challenged this by finding *dense* activation during motor learning… 🧵

Closing this Sunday!! #drosophila #Jobs

Over 50,000 annotations have been added to the connectome by the FlyWire community! This APL neuron, tagged by M. W. Pleijzier Zhihao Zheng, is 20x longer than a fly's whole body and is the longest cell in the brain. Proofread by labs of Greg Jefferis Murthy Lab @sebastianseung

Dear Colleagues, Please let your students and post-docs know about this great training opportunity. We will be covering both cellular resolution #brain #mapping and synaptic resolution EM #connectomics and how to bridge the two. Please RT! 1/2

Out in final form, our perspective on why the Julia programming language is well-suited to biology: nature.com/articles/s4159… Great to do this as part of the The Julia Language community: Adam MacLean, Huda Nassar, Dr. Chris Rackauckas, Tim Holy and led by Elisabeth Roesch, Michael P.H. Stumpf

From the most fabulous Zeynep, Pedro Jacob, Nils Otto et al. They fleas dae braw things wi thir wee heids. nature.com/articles/s4158…

Thrilled to share my PhD work, out in @nature today. Mehmet Fisek & I developed an all-optical approach to study long-range connectivity across brain areas. Upshot: visual feedback is spatially organized & nonlinearly integrated in V1 apical dendrites. nature.com/articles/s4158…

Please advertise our 3rd annual Autumn School on Computational Neuroscience, Neurotechnology and Neuro-inspired AI 25th-31st Oct 2023 in Ulster University, Derry/Londonderry, Northern Ireland Hybrid in-person/online ulster.ac.uk/faculties/comp…

🔥 Today, researchers unveiled the connectome of the male adult fruit fly nerve cord. 🧠 With about 23K neurons, 10 million pre-synaptic sites & 74 million post-synaptic densities, it’s the most in-depth & complete wiring diagram of a fly nerve cord. 🔗janelia.org/news/janelia-s…

Vous avez vu la dernière campagne marketing brillante de Nikon ? 📸 Face à la hype des IA génératrices d'images, Nikon prouve que le monde réel est plus beau que Midjourney. 8 clichés époustouflants avec des prompts insolites, révélant la splendeur inexplicable de la nature👇

Building the FlyWire #connectome from the FAFB brain was a massive team effort. But neuroscientists need to find their favourite neurons in this huge dataset. We report an indexed parts list, systematically annotating all 127k neurons (Schlegel et al biorxiv.org/content/10.110…) 1/7

The current wave of interest is a good time to also promote our recently updated paper on neurotransmitter prediction directly from EM (a task humans struggle with). This was used to add nts -> sign to the just released full brain Connectome. biorxiv.org/content/10.110…

I used Midjourney to imagine some of the most beautiful and famous mathematical theorems in the style of M. C. Escher. Here they are: 1. "The set of real numbers is uncountably infinite."

Introducing Neuropixels Ultra, a new probe with >10x site density: an implantable voltage camera capturing complete planar images of neurons' electrical fields in vivo! ⬆️ spike sorting yield, ⬆️ detection of small fields and ⬆️ cell type identification.🧵 biorxiv.org/content/10.110…

Sharing extraordinary work of Martin Carbó Tano with Mathilde Lapoix Cilia Jia Wyart Lab who identified the MLR in larval zebrafish, how MLR neurons encode vigor, and project onto reticulospinal neurons throughout the brainstem to elicit forward locomotion nature.com/articles/s4159…

New preprint: Suguru Takagi (Suguru Takagi) and Tom Auer (@tomtom_auer) - with many great collaborators - solve a simple (but actually hard) problem: how does having more sensory neurons for a given odour help an animal? The answer was unexpected ... 👇 biorxiv.org/content/10.110…

Statement from The Bloody Sunday March Committee on the reference by the Israeli Defense Forces to #BloodySunday. Please read and share. We are staggered beyond belief at at a post on X from the Israeli Defense Forces claiming that events in Israel are "Their Bloody Sunday."

Very excited to share the first manuscript out of my PhD presenting our analysis into the genetic architecture of gene expression and splicing using blood RNA-seq of 4,732 blood donors from the INTERVAL study. (1/7) medrxiv.org/content/10.110…

This one is very close to my heart, proudly sharing our newest preprint “Comparative connectomics of the descending and ascending neurons of the Drosophila nervous system: stereotypy and sexual dimorphism”. A short summary of this project that was 4 years in the making:

Big day for neuroscience & the end of the beginning for whole brain connectomics. Shout out to Sven Dorkenwald and Philipp Schlegel, first authors of the connectome papers, Murthy Lab Sebastian Seung for establishing #flywire to make this possible and Davi Bock for birthing this dataset.