What an exciting lineup 🤩for this Friday's Chicago Cytoskeleton Meeting! Join us for great science talks, followed by a poster session! 👩‍💻🧬

Our April cover ➡️ hubs.la/Q02r6l130 shows overlayed temporal projection of actomyosin dynamics in the leading edge of migrating mouse embryonic fibroblast expressing EGFP-non-muscle myosin & mScarlet F-Tractin. From Melissa Quintanilla, Jordan Beach et al. hubs.la/Q02r6jGp0

The cytoplasm of living cells can sustain transient and steady intracellular pressure gradients biorxiv.org/cgi/content/sh… #bioRxiv

impt advance in development of NM Myo2 inhib to aid in slowing GBM progression - congrats Courtney Miller, PhD MT-125 Inhibits Non-Muscle Myosin IIA and IIB, Synergizes with Oncogenic Kinase Inhibitors, and Prolongs Survival in Glioblastoma biorxiv.org/content/10.110…

Postdoctoral position to study myosin functions in immune cells and kidney disease at Upstate Medical University in Syracuse, NY. Affordable living, collaborative environment, and opportunities to use advanced microscopy and protein analysis techniques. bit.ly/4behKQK

The search is on.... We are recruiting at the assistant professor level! Come join us!!! Assistant Professor job with Loyola University of Chicago - Cell and Molecular Physiology Department | 12818067 (nature.com)

Excited to present a new story, where we use purified proteins to reconstitute repair of mechanical damage in contractile actin networks by the LIM domain protein zyxin.

Thanks to everyone who replied to this query - I appreciate your help and the resources shared! I have collected the references and links shared in this thread at kidneymyosin.com/cell-fixation-…

Ever wonder about the mechanics of immune cell #migration? Caillier Alexia, Patrick Oakes Loyola University Chicago and colleagues find T cells form integrin mediated focal adhesions to pull themselves through confined spaces. hubs.la/Q02Cjd1r0 #Immunology #Adhesion

T cells *do* make focal adhesions, and they need them! This updates (and somewhat complicates) our view of “amoeboid” vs “mesenchymal” modes of migration. Happy to see this out!

#FluorescenceFriday #cellbiology #immunology #Actin dynamics at the immunological synapse (IS) between a Jurkat T cell and an antigen-presenting coverslip, as seen by total internal reflection structured illumination microscopy (TIRF-SIM). John Hammer's group #NIH used our

more cool work from Jordan Beach lab on myosin 2 filament assembly - check it ou! Non-muscle myosin 2 can incorporate into established filaments in cells without an assembly competence domain biorxiv.org/content/10.110…

Took 1-8y off science for family during your postdoc or faculty position? Contact an NIH-funded lab to see if they will write a reentry with you. Please RT these little-known supplements: nigms.nih.gov/Research/Mecha…

A 🧵 about women applying for things. We’ve run a postdoc seminar series for the past few years. Our selection is entirely anonymized. We read only the research statements. No CV’s, no names, no lab references. But when all was revealed this year, 8/10 finalists were male.

Job alerts‼️ links in 2nd post Post-bacs: research assistant positions in the Zima and Jordan Beach lab PhD students: postdoc in Stefano Morotti in sunny CA Postdoc in #MullerLab (looking specifically for an ephys person) Post-docs: faculty position in our LoyolaPhysiology.

As always, this work is fully open sourced, and the Python code as well as the trained models can be found at github.com/WeisongZhao/SN… Please TRY it by yourself on your own data! (15/n)

We wrote a fun review all about the different types of mechanosensing and the ways cells regulate these important processes. Check it out!

How do you all stabilize flimsy expansion gels for imaging z-stacks? We’ve tried low melt agarose with some success.

Einstein's Arne, Ph.D., spoke to We Will Cure on the race to find a treatment for patients with genetic neurological disorders known as KAND. The professor of biochemistry shared how a 2022 XSeed Award helped him understand more about KAND. More at bit.ly/40vzMvn.

.The Economist is endorsing Kamala Harris for president. "We have editorials every week advising politicians around the world on what to do," says Editor in Chief Zanny Beddoes. "So it would be weird for us not to put that together and offer our assessment of a candidate."