🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

New preprint from the lab! 🚨 Replay of procedural experience occurs in the striatum and is independent of the hippocampus. Heroic effort by Emmett Thompson & the rest of the team Jasvin Kaur, Georgina Mills, Will Dorrell, Clémentine Dominé 🍊, Tom George 🧵👇1/13

It's days like this that make me LOVE my job! Our annual Shuman-Cai summer "bye bye" where we say farewell and congratulations to our team members moving on to their next adventure. Bittersweet memories of a day spent with the BEST people 💜

wrote up a little something about odor and spatial integration in the rodent brain. 🗺️🐀🌸 written with the twitter-less Nell Klimpert, Jason Ritt, and Alex Fleischmann :) Check it out ✨ frontiersin.org/journals/neura…

Today marks 3 big events: finishing residency, launching my lab Mount Sinai Psychiatry Friedman Brain Institute, & receiving my 1st R01: National Institute of Mental Health (NIMH) $4.2M BRAINS Award! Here’s to kicking off new beginnings + a warm welcome to my lab manager Sam Michael B. Pedersen, grad student Emma Andraka & the growing team!🧠🐁

It's out ‼️ 📢 Check out my PhD work with Kevin Bath! We find that early life adversity in mice disrupts central amygdala CRF+ neuron activity, augmenting the startle reflex in response to threat. doi.org/10.1038/s41467…

I defended my thesis last week! So grateful for the very generous support and guidance that my advisor Kay M Tye PhD gave me over the past 5 years, as well as for my amazing lab mates, my superstar team (Team LoneLee!), postdoc mentors, thesis committee, friends, and family. 🙏😁

It's finally out, on Joe's last day in the lab before heading off to postdoc! We asked whether a putative "social" brain area does anything unique with social cues when they're not used for any social reasoning. Turns out it does! nature.com/articles/s4146…

I'm thrilled to share that I'm joining BCM Department of Neuroscience as an asst prof starting Jan 2025! My group is broadly interested in how biological and artificial neural systems learn and adapt. We're looking for researchers at all levels to join us in this exciting endeavor. Stay tuned!

Excited to announce our new paper from Anthony Lacagnina (Brain Matters), Tri Dong, *et al.*, in which we show that extinction of contextual associations, whether aversive or appetitive, is governed by ventral hippocampal SST+ interneurons. cell.com/cell-reports/f…

📣 New Cai Lab paper in Cell Reports! We show that a stressful experience can produce different types of memories! We also find that the basolateral amygdala (BLA) & ventral hippocampus (vHC) differentially contribute to these memories 🧠 cell.com/cell-reports/f… More ⬇️ (1/6)

PRESS RELEASE! Joe Zaki Denise J. Cai, Ph.D., et al. uncover mechanism in brain that constantly refreshes memory ➡️ could have important implications for better understanding adaptive memory processes as well as maladaptive processes. nature👉tinyurl.com/ycxfmat2

DON'T MISS The Transmitter's GREAT OVERVIEW of TWO NEW STUDIES that "reveal how, during times of fear & stress, memories can become malleable..." HIGHLIGHTED, Denise J. Cai, Ph.D., et al.'s "Offline ensemble co-reactivation links memories across days" nature thetransmitter.org/memory/stress-…

❓ Do you know what the anterior hypothalamic nucleus (AHN) does? No? Neither did we! 🧠 In a new preprint from the Cai Lab, learn how we discovered the AHN’s central role in regulating stress vulnerability. Read the paper here: biorxiv.org/content/10.110…

THANK YOU Dr. Bertagnolli (@NIHDirector) for highlighting this important research by Joe Zaki, Denise J. Cai, Ph.D. et al.✨

Thank you @NIHDirector, Dr. Bertagnolli, for sharing my lab’s recent work! I’m so proud of the team and first author Joe Zaki for all the hard work they put into these exciting new findings about how memory-linking can shape our future experiences 🧠

📣 As promised, here is our protocol paper on chemotagging! This new technique combines calcium imaging with chemogenetics to identify cell types in commonly used Miniscope recordings & can be used to tag ANY CELL TYPE! Read about the technique here: biorxiv.org/content/10.110…

Astrocyte physiologists and computationalists! Imaging astrocyte structure and function, we discovered and quantified a spatial threshold to astrocyte calcium surge ⭐ doi.org/10.7554/eLife.…

Interested in how neural communication breaks down in a model of Alzheimer's pathology? In a new preprint, we found desynchronization in medial entorhinal–hippocampal circuits that coincided w/ the onset of spatial memory deficits in 3xTg mice. (1/6) biorxiv.org/content/10.110…

New paper out in Cell Reports! Led by Susie Yu Feng, we found that chronic epilepsy in mice drives distinct synchronization deficits in hippocampus and MEC, with early changes in HPC and late-onset changes in MEC that align with progressive memory deficits. cell.com/cell-reports/f…