In the Buchanan lab, Former Iowa MSTP Director student Ben Kreitlow investigates how the nighttime may increase risk of death following a seizure #DiscoverUI dare.research.uiowa.edu/kreitlow-ben/

Check out the latest issue of Genes & Development, cover image courtesy of our very own Professor Dan Eberl, PhD!

I often get overwhelmed with terminology in biology, especially when words have multiple meanings. To help me keep track of important terms in single-cell genomics, I made a "dictionary" of terms. Please feel free to contribute! github.com/sbooeshaghi/si…

I am excited to share our latest work PNASNews!! We show that airway ciliated cells express high levels of mitochondrial uncoupling proteins, UCP2 and UCP5. These proteins decrease mitochondrial protonmotive force and thereby reduce production of ROS! 👩‍🔬🧪pnas.org/doi/10.1073/pn…

Last year, the Make-a-Wish Foundation announced that kids with cystic fibrosis would no longer automatically qualify for a wish. This was, actually, a good thing—a great thing even!

Pediatric 🫀 failure + txp have risk for kidney failure & potential need for kidney txp following ped 🫀 txp. 👏👏 work by Iowa_MSTP student Lucas Barrett Lucas Barrett highlights prevalence & risk factors for subsequent kidney txp after heart txp. University of Iowa Ped Neph Fellowship UI Stead Family Department of Pediatrics Carver College of Medicine

What a PERFFect day to share our new preprint! With Tsion Abay #BobStickels Meril Takizawa @ChaligneRonan and Ansu Satpathy, we introduce PERFF-seq, a new experimental approach to studying rare cells with scRNA-seq via transcript-specific enrichment. biorxiv.org/content/10.110… 1/n

Exonic splice variant discovery using in vitro models of inherited retinal disease biorxiv.org/cgi/content/sh… #biorxiv_genetic

Excited to share this discovery: Huntington's disease is a DNA process for almost all of a cell's life. Inherited HD alleles are innocuous, just unstable – CAG repeats slowy expand throughout life, acquiring toxicity only when quite long (>150 CAGs). biorxiv.org/content/10.110…

Very happy to share our study of human photoreceptor cell development finally out today in Journal of Clinical Investigation! The cover image is an example of the sort of retinal organoids we used to model the inherited disease caused by NR2E3 variants. Check out those photoreceptors!!

Trying to see something Does the phrase “It has not escaped our notice” being to mind a specific finding/paper?

A single SNP in ~10% of US African Ancestry individuals causes a systematic decrease in HbA1c and a dramatic under treatment of diabetes. In Nature Medicine led by Joseph Breeyear Jacklyn Hellwege Ayush Giri Todd Edwards Vanderbilt University Medical Center nature.com/articles/s4159…

An MITF- and mTOR-dependent FLCN pathway suppresses TFE3-driven metastasis in melanoma biorxiv.org/cgi/content/sh… #biorxiv_cancer

Super excited to share that ENGRAM is out today! ENGRAM cells are programmed to write their histories into the genome, recording the intensity, duration, and order of biological events simultaneously. nature.com/articles/s4158…

Don't judge a book by its cover!? 📖 Happy to share our study of nonsynonymous variants that turn out to work by disrupting normal splicing in the retina. It appears that the NR2E3 R311Q variant causes enhanced s-cone syndrome through this mechanism!

Through the use of patient-derived retinal organoids, minigene assays, and in silico prediction, the latest Human Genetics and Genomics Advances study shows that nonsynonymous exonic variants can act through splice alteration in inherited retinal disease: cell.com/hgg-advances/f… Nate Mullin #ASHG

📢📢📢 Hot new paper led by our very own Yale School of Medicine A/Profs Nicole Lake Nicole Lake + Monkol Lek Monkol Lek on constraint in the mitochondrial genome. Superb work from a superb team!🤩🤩 nature.com/articles/s4158…

Delighted to share our recently published work in Nature Immunology. We show here that normalized microbial exposures in mice enhance memory T cell surveillance of the brain and modify seizure outcomes. nature.com/articles/s4159…

Anyone going to Woodman's in Essex this weekend? Here's what it looked like in 1977.