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Left a little gift in the Vassar College Bridge to start the spring semester. Thanks to Phil Knutson, PhD ⌬ for creating the original art design. #chemtwitter

Researchers have determined the biosynthetic pathway for a cyanobacterial toxin known as aetokthonotoxin (AETX). The toxin is made of two tryptophan molecules that are functionalized and then coupled. fal.cn/3mjqA

My paper with @Drennan_Lab on CODH gas channels is out in JIB! For this paper I got to use my favorite technique, which involves blasting crystals with xenon gas using a pressure cell. doi.org/10.1016/j.jino…

"Women & early-career scientists in academia were among those hardest hit by COVID-19 disruptions. Those who took on childcare, homeschooling or elder care found their lives & work completely upended." Read my story & others in ASBMB Today: #WomenInSTEM asbmb.org/asbmb-today/op…

First general meeting of 2022: ✅ CADI is back (in person)! It was great to hear about things happening in the department, learn about ways to get involved, and strengthen connections, both new and old. Stay tuned for more exciting events and community gatherings!

I still remember the talk you gave at our Intl student orientation 5 years ago. It was so encouraging and inspiring. That was our first time meeting a Vassar professor and was absolutely a great first impression.

Full version of our manuscript detailing an optimized expression and purification system for membrane proteins in liponanoparticles is now available! Access for free through June 7th here: authors.elsevier.com/c/1gxJ~_No-ZM0… MIT Biology

Like membrane proteins, CryoEM, mass spec, and glycans? Check out our latest preprint! biorxiv.org/content/10.110… Here, we map the structure of a protein involved in S. enterica O antigen biosynthesis without ever extracting it from a bilayer More below! #glycotime #massspec #cryoem

Congratulations to Dr. Zhuangyu Zhao Dmochowski Lab Penn Chemistry! He gave a dazzling Ph.D. defense today, showing how to tame xenon inside a protein. Next stop is @Drennan_Lab for postdoctoral training--very exciting! So proud of you, ZZ, and thanks for the custom Xe-129 hat!

We went on the hunt for halogenases with new substrate preferences and found much more than we bargained for! In a collab between MooreLabSIO and GerwickLab, we characterized the first enzyme capable of generating haloalkynes. A 🧵: pubs.acs.org/doi/10.1021/ja…

"Prof. McLaughlin is passionate about making the protein crystallography experience accessible to undergraduate students with a special focus on minorities currently underrepresented in research" Read more in this editorial featuring my Vassar College #CURE using @SSCGID & BASILbiochem!

Had a phenomenal time visiting MIT Chemistry as the seminar speaker! Was also awesome to hear about the cool work Naike Ye (my former advisee Vassar College ‘21!) is doing in @Drennan_Lab! Feeling energized from great conversations with students, postdocs & faculty! Thanks again!

Move over titin... introducing PKZILLA as the largest protein in life that makes one the largest nonpolymeric compounds in biology, the marine polyether toxin prymnesin. Congrats to Tim Fallon, PhD @[email protected] & Vikram Shende and rest of team! biorxiv.org/content/10.110…

Interested in membrane proteins? Come hang out with me and the folks at Cube Biotech this Wed at 11 AM EST. I’ll be sharing the latest on optimization of SMALP screening methods – lots of really cool data! Registration here: lnkd.in/gQy68ppR

Watch my students and I talk about our recently published research, and hear them share their experiences doing undergraduate research Vassar College! Grateful for the opportunity to do this as part of Structural Biology Communications's new initiative: Interviews with Authors (journals.iucr.org/f/issues/2024/…)!

Congratulations to Xiao Wang (Xiao Wang), the Cabot Assistant Professor of Chemistry and a Core Member of Broad Institute , who has been promoted to Associate Professor With Tenure, effective July 1, 2024. chemistry.mit.edu/chemistry-news…

Love story: serial crystallography Structural Biology

A single diiron #enzyme catalyses the oxidative rearrangement of tryptophan to indole nitrile by Sanjoy Adak, Naike Ye, Calderone, Duan, Lubeck, Schäfer, April Lukowski, Ken Houk, Pandelia, @Drennan_Lab, & Bradley Moore MooreLabSIO in Nature Chemistry nature.com/articles/s4155…

Excited to see this work out! Read here about the methanogenic CO dehydrogenase/acetyl-CoA synthase structure: pnas.org/doi/10.1073/pn… And here about the challenges of obtaining it: chemistry.mit.edu/chemistry-news…

Our lab's latest paper. This is so exciting!! This paper is literally 10 years in the making, and it is bringing me great joy to see it published. Also the figures in it are 🔥so you should give it a read! x.com/biophyskrys/st…