Older onset MS correlated with shorter time to disability

Ovarian aging associated with gray matter volume loss and disability in women with MS

Cognitive impairment occurs in all subtypes of MS including 35 percent of clinically isolated syndrome subtype #ectrims2025

24 percent of radiological isolated syndrome patients are reported to have cognitive impairment #ectrims2025

SWI can detect paramagnetic rim lesions #ectrims2025

PRL’s rarely seen in non MS conditions

SEL’s slowly expanding lesions can predict progression over time and can be detected on conventional MRI #ectrims2025

PET imaging can detect hidden pathology within and at edge of white matter lesions and NAWM #ectrims2025

Higher density of activated microglia have greater TSPO presence . PET ligand binds to TSPO #ectrims2025

Effects of glial activation in MS #ectrims2025

Trial assessing A2AR antagonist treatment on glial activation using PET imaging #ectrims2025

Dalla Costa: #MS patients with highest ultra-processed food #UPF intake quartile experienced about 30% more relapses over five years compared to those with the lowest intake. High #UPF intake? More active MRI lesions. #DietMatters #ECTRIMS2025

Late Breaking #ECTRIMS2025. Prof Giovannoni presents the first study demonstrating the benefit of a DMT (ocrelizumab) in pwMS who are EDSS > 6.5

However great the work that God may achieve by an individual, he must not indulge in self-satisfaction. He ought rather to be all the more humbled, seeing himself merely as a tool which God has made use of. - Saint Vincent de Paul ⚜️

Paramagnetic rim lesions (PRLs) [dark lesions on SWI sequences in multiple sclerosis] appear to be a phenomenon associated with relatively newer lesions. In this study, PRLs were only present in lesions formed within the last 5 years. pubmed.ncbi.nlm.nih.gov/41019415/

"Start by doing what's necessary; then do what's possible; and suddenly you are doing the impossible." -St. Francis of Assisi on his feast day

St. Francis of Assisi says: “We must be simple, charitable, humble, and pure.” When we live in such a way, we are instruments of the Lord’s peace and reflect his image to others. With God’s grace, may we walk in the footsteps of Francis today and always.

Disease reactivation occurred after 40.5 months from only two ocrelizumab courses in 6/19 (32%) participants with #MultipleSclerosis vs 0/52 propensity-score-matched participants with continued treatment. Results of two open-label trials Johns Hopkins University ▶️ journals.sagepub.com/doi/abs/10.117…

Management of Monoclonal Gammopathy of Undetermined Significance. In low-risk patients who are younger than 50 years of age, bone marrow biopsy and imaging may be considered a baseline evaluation, given the anticipated life expectancy. Learn more: nej.md/473uOsj

Our ancestors didn’t wait for opportunity — they created it. With no shortcuts, no guarantees, and no safety nets. Their bakeries, delis, butcher shops, and family businesses weren’t just places to make a living… they were places that gave neighborhoods a heartbeat. Every