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Older individual with encephalopathy of unknown cause, proteinuria and acute kidney injury. Bx showed focal intravascular CD20+ large B cell lymphoma and collapsing glomerulopathy. Related?

Patient taking quinine has laboratory TMA findings and negative serologic studies. Biopsy shows severe tubular injury and glomerular-limited TMA with extensive thrombosis and focal endocapillary pmns due to quinine-dependent antibodies reactive with platelets and neutrophils.

Middle age man, hgbA1c 5.8, glucose 111, hematocrit 9.2, UPC 9.6g/g, Screat 5. Biopsy shows advanced nodular glomerulosclerosis, then found to have diabetic retinopathy. Glycated albumin and glucose tolerance test can further assess for diabetes with anemia and normal A1c.

Globally sclerotic glomerulus masquerading as an occluded artery on a deeper section.

End stage kidney transplant with massively thickened PTC walls and PTCitis in a sea of fibrosis. CD34+ in endothelium, fibrin+ and >30 PTC BM layers.

Glomerular Diseases (Karger journal) is now PubMed indexed! Check out the 13th International Podocyte Conf abstracts at karger.com/Article/Pdf/52…

Bland Class V membranous lupus with extensive diffuse circumferential deposits in arteries and arterioles.

Glomerular Diseases is now PubMed Indexed. Check out the issue on IgA nephropathy. karger.com/Journal/Issue/… GDZ welcomes your manuscript submissions at karger.com/Journal/Submis….

Focal segmental podocyte reaction to intracytoplasmic and intramembranous calcium deposition associated with very high serum Ca++ level.

Guess the vacuole etiology. Importance of clinical-pathologic correlation.

FSGS with usual features but 1 glom with foamy macrophages containing cholesterol crystals in segment of sclerosis. No lipid disorder. Unusual finding.

Amyloid causing GBM break and crescent with inflammation. An uncommon but not rare event in amyloidosis.

Young person found down with moderately elevated CK level and acute kidney injury. Tubular cell reabsorption of myoglobin causing vacuolization and abnormal lysosomes. No myoglobin casts present.

How to tell the difference? Microcystically dilated tubules (arrow) and tubular thyroidization (chevron) in the same tissue core.

Hispanic woman with ANCA-associated crescentic GN and incidental focal interstitial amyloid (ALECT2). A not uncommon finding in this patient demographic.