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Rational immunosilencing of a promiscuous T-cell epitope in the capsid of an adeno-associated virus rdcu.be/drSs6

VERY excited to welcome this paper out in Nature Biomedical Engineering where we introduce the GEMINI platform for engineering multifunctional extracellular vesicles as versatile, programmable, biological delivery vehicles nature.com/articles/s4155…

Identification of druggable regulators of cell secretion via a kinome-wide screen and high-throughput immunomagnetic cell sorting rdcu.be/dr9Ag

Engaging natural antibody responses for the treatment of inflammatory bowel disease via phosphorylcholine-presenting nanofibres rdcu.be/dr9Bd

Tachycardia-induced metabolic rewiring as a driver of contractile dysfunction rdcu.be/dr9Bt

Ultrafast longitudinal imaging of haemodynamics via single-shot volumetric photoacoustic tomography with a single-element detector rdcu.be/dssVZ

Photoacoustic vector tomography for deep haemodynamic imaging rdcu.be/dssWq

High-dimensional multi-pass flow cytometry via spectrally encoded cellular barcoding rdcu.be/dssXa

Modular chimeric cytokine receptors with leucine zippers enhance the antitumour activity of CAR T cells via JAK/STAT signalling rdcu.be/dssXU

Genetically encoding multiple functionalities into extracellular vesicles for the targeted delivery of biologics to T cells rdcu.be/dstQR news.northwestern.edu/stories/2023/1…

What if you could use generative AI to explain how a black box AI model makes its decisions? Hot off the press Nature Biomedical Engineering, first author Alex Degrave of Allen School developed a model that could create counterfactuals to help explain medical AI devices. nature.com/articles/s4155…

A very clever way to understand the reasoning process of complex medical #AI using counterfactual images and expert clinicians, transcending saliency maps nature.com/articles/s4155… Nature Biomedical Engineering Su-In Lee Roxana Daneshjou MD/PhD Allen School H/T Pranav Rajpurkar

I’m recruiting two editors for our close-knit multidisciplinary team. The role involves constant learning, and offers flexibility in self-management and a sensible balance of independence and collaborative teamwork. careers.springernature.com/job-invite/496…

Only a month away from #NanomaterialsManipal2024 featuring Twan Lammers Mike Mitchell Li Tang Ariel Furst Jinming Gao Lab Marianne Ashford and more speakers in person! Book your seat conferences.nature.com/NwwOaY?RefId=T… Produced by Manipal Academy of Higher Education Nature Communications Nature Nanotechnology

We are recruiting one more editor for our close-knit multidisciplinary team. We seek candidates who are resourceful, open-minded, decisive and diligent. We will start reviewing applications from May 6. careers.springernature.com/job-invite/496…

Today we report in Nature Biomedical Engineering the eePASSIGE system, which uses evolved and engineered recombinases and prime editing to integrate large gene-sized DNA cargoes into the mammalian genome in an efficient, precise, and targeted manner. (1/13) drive.google.com/file/d/1WDMVqL…

(1/11) Antimicrobial resistance is one of the greatest threats of our time, and novel antibiotics are urgently needed. Today, we report in Nature Biomedical Engineering the AI-driven discovery of tens of thousands of antibiotics in extinct organisms. nature.com/articles/s4155…

🔬In latest Nature Biomedical Engineering paper, we introduce a new platform for clinician+AI collaboration: nuclei Most medical AI is one-size-fits-all. But different clinicians have diff use cases/requirements. Nuclei enables user to rapidly personalize AI via active QA nature.com/articles/s4155… 1/4

Today we report in Nature Biomedical Engineering the systematic application of six recent prime editing developments to enable efficient and functional correction of CFTR F508del, the predominant mutation that causes cystic fibrosis (CF), in primary airway cells from CF patients.

Scientists have developed a prime editing approach that efficiently corrects the most common cystic fibrosis mutation in human lung cells, which could pave the way to a one-time treatment as effective as existing daily therapies. broad.io/CF-PrimeEditin…