💡Thinking of using scRNA-seq to design antibody panels for spatial or single-cell profiling? Happy to launch Cytomarker, an interactive web-app and new antibody screening strategy to design and validate custom panels 1/6

Why are older individuals more prone to neurodegenerative diseases? Very excited to share our new #bioRxiv from Joe Ecker. We study age-related epigenetic changes in the brain, highlighting on cell-type-specific transposon demethylation and TAD remodeling. We also present a deep

You: waiting for the reviews for 4 months The reviewer:

KLRG1 identifies regulatory T cells with mitochondrial alterations that accumulate with aging Nature Aging nature.com/articles/s4358… Mittelbrunn Lab Gonzalo Soto-Heredero

Brain-wide microglia replacement using a nonconditioning strategy ameliorates pathology in mouse models of neurological disorders science.org/doi/10.1126/sc…

Excited to share our new work demonstrating a role for astrocytic inflammasome signaling in modulating hippocampal plasticity. All credit to Kristine Zengeler, who was the brains🧠 and muscle💪 behind this project and is a wonderful collaborator.

Online now! Soto-Heredero et al. show that Tregs characterized by the expression of KLRG1 accumulate with age in both mice and humans, and exhibit features like mitochondrial decline and an inflammatory phenotype. doi.org/10.1038/s43587…

Chronic stress drives depression by disrupting cellular housekeeping nature.com/articles/d4158…

Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration nature.com/articles/s4358…

A dynamic and multimodal framework to define microglial states🔥 nature.com/articles/s4159…

A dynamic and multimodal framework to define microglial states | Perspective | Nature Neuroscience #microglia #brain #singlecell nature.com/articles/s4159…

Absolutely thrilled to share with you the final version of EPIclone, out now (open access) in nature. This has been an amazing collaboration with the lab of Lars Velten (@larsplus) at Centre for Genomic Regulation (CRG) nature.com/articles/s4158…

Excited to share the first of many works out of Justin Milner. Be sure to check it out! Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment: Immunity cell.com/immunity/fullt…

Way to go Milner lab!! 🤩

How well do single-cell foundation models perform w/o finetuning? Our work Genome Biology shows that in zero-shot settings, scGPT and Geneformer often underperform traditional methods, raising questions about their utility for biological discovery. 📰 genomebiology.biomedcentral.com/articles/10.11…

Next week, join UNC Computer Science expert Gedas Bertasius for, "From Cooking to Basketball: Human Skill Learning in the Age of AI." The engaging lecture explores how #AI shapes the ways we learn human skills 🗓️ Tues., June 3 ⏰ 6:30 p.m. 📍 The Friday Center go.unc.edu/Aq73T

1/4 🚨 New Outlook in Genes & Development: "Scaling life as an interspecies hallmark of aging" We propose temporal scaling as a new hallmark—linking lifespan diversity to conserved aging mechanisms. 🔗 tinyurl.com/3a4wawym Hebrew University HUJI Department of Genetics

Thank you for sharing our microglia replacement study! In 2020, we achieved efficient microglia replacement for the first time (PMID: 32783928). After that, we took another 5 five years to demonstrate its clinical feasibility and efficacy. We truly believe that microglia

Dynamic fibroblast–immune interactions shape recovery after brain injury | Nature nature.com/articles/s4158…

Autoimmune response to C9orf72 protein in ALS. Implicates targeting T cells and boosting Tregs as potential therapeutic strategies to treat ALS. nature nature.com/articles/s4158…