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Research Highlight by Arunima Singh: "Chemical space exploration with quantum computing" nature.com/articles/s4159…

Research Highlight by Lin Tang: "Optimal transport for single-cell genomics" nature.com/articles/s4159…

Research Highlight by Rita Strack: "Structural biology at the plasma membrane" nature.com/articles/s4159…

Our April issue is live! 🌧️🌷 nature.com/nmeth/volumes/… On the cover, Spotiphy projects scRNA-seq and histological image data onto the spatial transcriptome. Artwork by Jiyuan Yang St. Jude Research. Paper: nature.com/articles/s4159…

Out this week from the MICrONS consortium: CAVE, Connectome Annotation Versioning Engine, a platform for proofreading, annotating and analyzing petascale EM datasets. nature.com/articles/s4159…

Phylogenetic compression achieves performant and lossless compression of massive collections of microbial genomes, facilitating fast BLAST-like search and versatile alignment tasks. Karel Břinda @Baym @inria DBMI at Harvard Med nature.com/articles/s4159…

Perturb-tracing integrates CRISPR screening with barcode readout and chromatin tracing for loss-of-function screens, facilitating the study of chromatin folding regulators. Siyuan (Steven) Wang Yale School of Medicine Yale University Yale Department of Genetics Yale Cell Biology nature.com/articles/s4159…

PTM-Mamba: a post-translational modification-aware protein language model, for protein modeling and design. nature.com/articles/s4159…

The integration of duplex sequencing with cost-effective Ultima sequencing enhances the accuracy of whole-genome circulating cell-free DNA profiling. Dan Landau Alexandre Pellan Cheng nature.com/articles/s4159…

Read the News & Views highlighting this cool work here! nature.com/articles/s4159…

In this month's Editorial we discuss why basic research is the backbone of advances in medicine and improvements to the human condition - and that basic research needs essential support from government funding. nature.com/articles/s4159…

A Perspective from the Ecker lab discusses the progress and challenges of using computer vision approaches for behavior studies of primates in natural environments. nature.com/articles/s4159…

Research Highlight by Lei Tang: the Doudna lab introduces a type III-A CRISPR–Csm RNA-targeting system for imaging native individual transcripts in cells. Original paper: nature.com/articles/s4158… Highlight: nature.com/articles/s4159…

Research Highlight by Madhura Mukhopadhyay: Learning the immunological repertoire. Original paper: science.org/doi/10.1126/sc… Highlight: nature.com/articles/s4159…

Research Highlight by Arunima Singh: Understanding protein subcellular compartmentalization signals. Original paper: science.org/doi/10.1126/sc… Highlight: nature.com/articles/s4159…

An excellent Review out today from Jonathan Liu and colleagues discusses current 2D and 3D microscopy methods for imaging three-dimensional cell cultures and emerging strategies to address key challenges. nature.com/articles/s4159…