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Another type of Aβ42 fibril (type III) has been identified in the soluble fraction of an Alzheimer’s disease brain using cryo-EM. The different types are also revealed to have different ligand-fibril interactions. nature.com/articles/s4158…

A study on two synaptic proteins reveals that phase separation-mediated formation of molecular condensates and network complexity within condensates can change the biomolecular interaction specificities of these proteins nature.com/articles/s4158…

Here, the authors engineer and evolve an orthogonal malonyl-CoA pathway in E. coli to improve its metabolism, increasing malonyl-CoA levels, and polyketide yields nature.com/articles/s4158…

A new paper reports the genomic discovery and biochemical characterization of a widely distributed gene cluster family for briarane diterpenoid biosynthesis in metazoans nature.com/articles/s4158…

Folate receptor alpha-targeting chimeras (FRTACs) are developed for targeted membrane protein degradation by conjugating multiple folate molecules to antibodies. The folate polyvalency enables high affinity and potency of FRTACs to target proteins nature.com/articles/s4158…

A modular protein engineering strategy is developed to shuttle transporters and integral membrane enzymes folded in the ER to the peroxisomal membrane. This expands the repertoire of biosynthetic pathways that can be compartmentalized in the peroxisome nature.com/articles/s4158…

A new Perspective by Mark Howarth discusses click biology as an analogy to click chemistry, examines reactions using building blocks present in living cells, and highlights opportunities for fundamental research and synthetic biology nature.com/articles/s4158…

Our latest work is out in Nature Chemical Biology Nature Chemical Biology and featured by Penn Engineering: We discovered new fungal RiPPs, aspergimycins, from Aspergillus flavus, with promising anti-leukemia activity via lipid modification. blog.seas.upenn.edu/penn-engineers…

RFpeptides is an extension of RoseTTAFold2 and RFdiffusion and combines structure prediction and protein backbone generation for rapid and custom de novo design of macrocyclic peptide binders nature.com/articles/s4158…

Thrilled to see our work published in Nature Chemical Biology! Huge congratulations to Fumiya, Kota, Kazuhiro, and the incredible team🎉 “Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R” doi.org/10.1038/s41589…

“A transposon-like strategy for proteins” - A News & Views by Barbara Di Ventura highlights recent work Science Magazine on using transposition, normally considered a DNA-based process, for protein semisynthesis and site-specific modification nature.com/articles/s4158…

Cysteine dioxygenase (CDO1) is identified as a small-molecule glue target for the von Hippel-Lindau (VHL) E3 ubiquitin ligase and induces VHL-dependent proteasomal degradation of CDO1 in cells nature.com/articles/s4158…

Here, the authors report the identification of TSB-like, a pseudoenzyme that hijacks an enzyme of tryptophan biosynthesis to produce indole nature.com/articles/s4158…

A new Perspective by Anastasia Croitoru, Asuka Orr, and Alex MacKerell discusses how computational methods can be used to facilitate the early-stage development and optimization of antibody-drug conjugates nature.com/articles/s4158…

Here the authors use structural and mechanistic investigations to identify the key features of BesB that allow it to form a terminal alkyne-containing amino acid using pyridoxal phosphate as a cofactor nature.com/articles/s4158…

Dysregulated R-loops can compromise genome stability. Here, the authors demonstrate that R-loop-induced PARP1 activation orchestrates EXD2-mediated R-loop resolution, thereby safeguarding genomic integrity nature.com/articles/s4158…

Structural studies unveil a two-step catalytic process of actin-activated phosphoryl-AMPylation by Legionella effector LnaB, providing a biochemical basis for AMPylation nature.com/articles/s4158…