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Modeling suggests that tau tangles advance through the brain primarily via axonal connections, not local transmission. #alzheimersdisease #mcgill #lunduniversity ow.ly/3uF150zUtN3

New study from Cherry et al. & VA-BU-Concussion Legacy Foundation Brain Bank further clarifies the pathology found in the hallmark #CTE brain lesion. Results will be crucial to better differentiating CTE from age-related changes & similar diseases. onlinelibrary.wiley.com/doi/abs/10.111…

Veksler et al. reveal slow blood-to-brain transport in a subset of amateur American football players, using a modified MRI-based method that can detect subtle, region-specific blood-brain barrier dysfunction. bit.ly/2zEI0at

New abstract: #CTE is associated with TDP-43 Retinal Pathology. 7/8 stage IV CTE patients (vs 1/8 controls) had abnormal cytoplasmic accumulation of pTDP-43 in the retina. These findings may underlie the visual symptoms reported in patients with CTE. iovs.arvojournals.org/article.aspx?a…

Using MRI to look at the brains of female rugby players at Western University, researchers have shown mild hits cause changes even in healthy, symptom-free athletes. “The repetitive impact clearly had effects on the brain,” says Ravi Menon, PhD (@northernthrux) schulich.uwo.ca/about/news/202…

Neuroplasticity is the brain’s ability to rewire itself after injury. Western University’s Arthur Brown, PhD, is harnessing this power and researching new ways to treat concussion. The final video in our four-part series, Brainstorm: Straight Talk on Concussion, launches June 25.

New study identified blood #biomarkers that could help to predict which athletes need additional time to recover from a sports related concussion. nih.gov/news-events/ne… #NIHresearch

New study: Cumulative contact sport exposure to repetitive head impacts (RHI), but not diagnosed #concussions, is associated with subtle differences in white matter microstructure in the brains of young active athletes. Let's stop hitting kids in the head. liebertpub.com/doi/10.1089/ne…

People with a history of #concussion report trouble concentrating and higher levels of anxiety and depression. Western University’s Adrian Owen, PhD (Prof. Adrian M. Owen OBE, FRS) is investigating the long-term cognitive effects of concussion, including deficits in inhibitory control.

This discovery of a mechanistic link between #CTE and #ALS was made possible thanks to the generous families who donated the brain of a loved one to the VA-Boston U Chobanian & Avedisian School of Medicine-Concussion Legacy Foundation Brain Bank. We need more research on this. n.neurology.org/content/90/5/e…

'Cellular and molecular mechanisms of pathological tau phosphorylation in traumatic brain injury: implications for #ChronicTraumaticEncephalopathy' Neil Donison Neil Donison Jacqueline Palik, Kathryn Volkening, Michael J. Strong Western University #tauopathy …arneurodegeneration.biomedcentral.com/articles/10.11…