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11/ To really get our heads scratching. Here is the pre-print that maps the biology of this. Stefan Pohlmann's work in 2014 on SARS CoV-1 was key here! biorxiv.org/content/10.110…

Our review of #IAS2023 is out in HIV Medicine! Thank you to my co-authors @tristanjbarber & Yusuf H. W. We cover a range of topics including, of course, REPRIEVE Trial doi.org/10.1111/hiv.13…

Congratulations to our PhD student Janna Jamal Eddine for being awarded the ViiV Healthcare Australia Young Investigator prize at the Melbourne World AIDS Day event. RMIT Research Doherty Institute ViiV Healthcare #hivcure #worldaidsday2023 mHIVE ACH4 Living Positive Victoria - LPV

Evolutionary trajectory of SARS CoV-2 from Ancestral Clade A to JN.1. What does the below mean? The virus is consolidating towards a specific pool of ACE2. Early on the ACE2 pool the virus favoured needed to be cut/cleaved. Now it heavily favours (well for JN.1) uncleave ACE2.

Work in progress here: biorxiv.org/content/10.110…

Are CNS (brain) reservoirs transcriptionally active on #HIV treatment? Prof Melissa Churchill from RMIT University Neuroinfections Lab says yes & this can contribute to viral reactivation. Lots of evidence that an #HIVcure must consider reservoirs such as the brain. More on this later.

Sharon Lewin from Doherty Institute speaking on #HIV Persistence in the CNS and the considerations for Cure Strategies at #CROI2024

Get to know your immune system at one of our FREE upcoming events! The Day of Immunology is fast approaching and to celebrate we have events running in Melbourne, Sydney, Perth, Brisbane, and Auckland. See the great opportunities and register at dayofimmunology.org.au

The best time of year! It's almost Day of Immunology, what will you be doing to celebrate your immune system in 2024? #DoImmuno #DayofImmunology 🧪🔬🦠

Congrats to PhD student Janna Jamal Eddine on her first author PLOS Pathogens publication. Great collab with RMIT Research Doherty Institute OHSU News #hivcure This study identified persistent HIV transcription in brain tissue from virally suppressed PWH dx.plos.org/10.1371/journa…

Super excited to be part of the #HIV unwrapped project, showcased at #HIVAIDS2024 Researchers were teamed up with RMIT University fashion design students who designed a lab coat based on the science. Check it out if you’re here! ASHM

Very happy to see Prof Melissa Churchill from RMIT University Neuroinfections Lab speaking HIV reservoirs in the brain at #HIVAIDS2024 plenary session. It’s so important to understand the implications on cognitive comorbidities and #HIVcure ASHM HIV cure

Am also very grateful that Prof Churchill took the time to explain the assays used in labs to measure and characterise the reservoir, including transcription profiling shown here. Good on #HIVAIDS2024 for showcasing this important work to the diverse conference audience

A brilliant talk summarising everything you need to know about CNS reservoirs ends with some points to ponder for #HIVcure - reaching CNS reservoirs, CNS toxicities, and designing Cure trials considering safety (particularly with treatment interruptions)

New research shows HIV continues to transcribe in the brain of virally suppressed individuals, potentially explaining #neurocognitive issues. This finding has key implications for #HIV cure research & CNS-targeted therapies. bit.ly/4eya510 #PLoSPathogens Neuroinfections Lab

We are so excited to see the next iteration of CLOAK take place with ASHM & RMIT University RMIT Research Here's SSSHARC Director Lee Wallace at 'HIV Unwrapped 2024: a re-imagination of the lab coat'. Read more about CLOAK here sydney.edu.au/arts/news-and-… ashm.org.au/about/news/hiv…

On display Doherty Institute 22-24 OCT! A unique collab between Victorian HIV researchers and RMIT University fashion students, to create a series of lab coats which reflect the exceptional work being done in HIV science in Victoria🎫 go.unimelb.edu.au/rxg8

An #HIV reservoir in the brain?!Fascinating flash talk by Janna Jamal Eddine from Neuroinfections Lab at VIIN #VIINYIS #YoungVIIN2024

HIV transcription persists in the brain of virally suppressed people with #HIV Co-authors include DARE researchers Profs Sharon Lewin and Jake Estes In PLOS Pathogens #HIVcure buff.ly/3O1z5Cz

New Research: Neuroinflammation associated with proviral DNA persists in the brain of virally suppressed people with HIV frontiersin.org/articles/10.33… #FrontiersIn #Immunology