In this research article, Nguyen et al. identified Mfsd7c as a choline exporter at blood–brain barrier. This discovery paves the way for modulating choline and acetylcholine levels for treatment of neurological disorders such as Alzheimer’s disease. nature.com/articles/s4142…

Yuanzheng He’s group identifies oleic acid as an endogenous ligand of GPR3, revealing the essential mechanism behind GPR3 activation in cold-induced thermogenesis through a model of “born to be activated and cold to enhance”. nature.com/articles/s4142…

Biallelic variation in the choline and ethanolamine transporter FLVCR1 underlies a pleiotropic disease spectrum from adult neurodegeneration to severe developmental disorders medrxiv.org/cgi/content/sh… #medRxiv

Preprint work with Kevin Lynch UVA Pharmacology. We developed #Spns2 inhibitors and showed efficacy in #MultipleSclerosis mouse model + no cardiac & auditory side effects. Biomarker=lymphopenia. Builds a case for drugging #Spns2. Virginia Tech Chemistry Virginia Tech Science biorxiv.org/content/10.110…

Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models: buff.ly/4aTi47m long nguyen Yong Loo Lin School of Medicine #Aging #Metabolism

Read more: medicine.nus.edu.sg/news/little-kn…

Orphan transporters! ⁦RESOLUTE - Research Empowerment on Solute Carriers⁩ ⁦Transporters and Solute carriers⁩

Very happy to share a collaborative work with Safarian Lab Di Wu and others for the structures & functions of human Mfsd7b/Flvcr1 and Mfsd7c/Flvcr2 that just came out in Nature nature.com/articles/s4158…. Fantastic team work 💪🏿. Thank you 🙏

Tracking down rare diseases: Researchers from our Institute, Fraunhofer ITMP, NUS, University of Washington & Goethe-Universität studied the structure & cellular function of #FLVCR proteins paving the way to understand the progression of rare diseases & develop new therapies👉biophys.mpg.de/tracking-down-…

Mutations in MFSD7c (Flvcr2) are linked to #Fowler syndrome; this new Slovene-international study reveals it as a choline transporter at the blood brain barrier, impacting #brain choline levels and providing insights into disease mechanisms. ncbi.nlm.nih.gov/pmc/articles/P… #EARA #InMice

Loss of SPNS1, a lysosomal transporter, in the nervous system causes dysmyelination and white matter dysplasia biorxiv.org/cgi/content/sh… #biorxiv_cellbio

📣 There are still some spaces left for the Membrane Transport Proteins GRC/GRS in Maine. Check out the website for the full program and registration details; grc.org/membrane-trans… Gordon Research Conferences Marco Niello Susie L Ingram

I'm hiring! Interested in lysosomal biology and/or lysosomes and neurodegeneration? The Damme lab is recruiting PhD students and PostDocs! DM or tinyurl.com/yrv4bh22 Get in touch with me! Repost & spread the word!

📢Excited to share our latest study out in CardiovascularResearch where we fine-map the zonation and engagement of S1PR1 signaling in the murine blood and lymphatic vasculature! Kevin Boye Mathilde_poulet Long Nguyen academic.oup.com/cardiovascres/… European Society of Cardiology Journals #CardiovascularResearch

Molecular basis of Spns1-mediated lysophospholipid transport from the lysosome | PNAS pnas.org/doi/10.1073/pn…

Short Talk Abstract Deadline: Tuesday 28th January 2025 - You can submit an abstract to be considered for a short talk at the Keystone Symposia Lipids in Cellular Function and Disease Meeting. For more information click the link: keystonesymposia.org/conferences/co…

The Keystone Symposia on #Lipids in Cellular Function & Disease will feature a @Jlipidres Lectureship Award! Check out the program: bit.ly/4jnPsYg. Details: 📅📍April 6–9, 2025 in Breckenridge, CO. ⏯️ Valerie O'Donnell (Cardiff University) on #KSLipids25: youtube.com/watch?v=-ABv89…