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Fantastic collaboration between Boehringer Ingelheim & Genomics England colleagues to identify novel variants and genes associated with Idiopathic Pulmonary Fibrosis (IPF) risk. Hopefully at least one will turn out to be a good drug target for IPF and/or related diseases! #IPF

It took me SEVEN years to figure out that you can save a ggplot as a vectorized .svg file ggsave("file.svg"). The svg file can be opened on powerpoint and it will be completely vectorized, even text are still recognized as text boxes! No more recreating plots on illustrator!!!!!

GWAS by SCALLOP Consortium on 92 proteins of Neurology panel (N=12,176) and 92 proteins of Neuro-Exploratory panel (N=5,013) by Olink 👉125 cis- & 164 trans-pQTLs • Summary stats:📊datashare.ed.ac.uk/handle/10283/8… • Paper:🔒nature.com/articles/s4156… • Preprint:📜medrxiv.org/content/10.110…

🤯750k WGS/WES (UKB, MGB, AoU) rare variant gene discovery across 601 traits from Sean Jurgens Patrick Ellinor and co. Results are viewable and downloadable via their browser: hugeamp.org:8000/research.html?… nature.com/articles/s4158…

I am so honoured for this invitation and I am very much looking forward to this conversation on Friday! Join us, details below, and keep an eye out for future My Science Journey events!

Excited for our protein risk score and mortality in individuals who smoke paper to come out: nature.com/articles/s4159… Fun collaboration and interesting findings with respect to respiratory vs cardiovascular mortality. Michael Cho Yohannes Tesfaigzi Ani Manichaikul Iain Konigsberg

Identifying the causal genes driving GWAS signals remains a challenge🧬 New study compares methods to detect causal genes by integrating eQTLs 👉evidence from both colocalization & Mendelian randomization maximizes precision at a cost of low recall🎯 🔗cell.com/hgg-advances/f…

Presented my poster on improved fine mapping of lung fibrosis signals using multi-trait analysis at #ICLAF2024

Our latest EXCEED newsletter is now available to view on our webpage: exceed.org.uk/news/

Happy to share our work using genetics and transcriptomics together for subtyping COPD patients. We found heterogeneity within high risk groups, showing a group with greater lung function decline and another more severe group. Many thanks eBioMedicine – The Lancet Discovery Science sciencedirect.com/science/articl…

This Cell paper making the most of the #proteomics resource of the UK Biobank is a great Sunday read📖❗️ 🔗cell.com/cell/fulltext/… It highlights at scale the areas, where proteomics could provide meaningful insights: 🧵

Introducing a new method called REMETA from the Regeneron Genetics Center (RGC) Regeneron Genetics Center for meta-analysis of gene-based tests using summary statistics rgcgithub.github.io/remeta/ This is great work from Tyler Joseph. Pre-print is here​ medrxiv.org/content/10.110…

JOBS | Research Associate in Genomic Epidemiology of Severe Asthma FT/PT (min 0.8FTE, 30 hrs/wk) or job share considered Fixed term contract for 30 months Funded by MRC Closes 18 Feb jobs.le.ac.uk/vacancies/1083…

News | Local research study contributes to global findings which pinpoint genes for depression across ethnicities 👉le.ac.uk/news/2025/janu… The study identified genetic risk factors, allowing scientists to predict risk of depression. Catherine John| EXCEED Study

JOBS | Research Associate for project on statistical methodology for prognostic models FT/PT (min 0.5FTE, 18.75 hrs/wk) or job share considered Fixed term contract until 28/2/26 Funded by NIHR Closes 12 Feb Sarah Booth Mark Rutherford Biostatistics: Uni of Leicester jobs.le.ac.uk/vacancies/1132…

A chronic obstructive pulmonary disease (COPD) polygenic risk score enhances the identification of undiagnosed COPD beyond a conventional case-finding approach in the general population. ja.ma/3Cssm23

JOBS | Research Associate in genetic epidemiology of quantitative lung function, as relevant to respiratory diseases FT/PT (min 0.6FTE, 22.5 hrs/wk) or job share considered, fixed term contract for 24 mths Funded by Wellcome Trust Closes 12 March jobs.le.ac.uk/vacancies/1120…

Past eQTL studies have mostly focused on one gene at a time. But in the human genome, genes often occur in clusters and tend to be co-regulated by shared mechanisms. So why not consider neighboring genes together when mapping eQTLs? A new preprint tests this idea and introduces

We are excited to announce that Om Kurmi will be a speaker at our Respiratory Genomics Conference in November. You can read about the Nepal Family Cohort Study here: nepalstudy.org