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Rationale and Design of NUDGE-CKD: A Nationwide Randomized Factorial Trial of Electronic Nudges for Increasing Guideline-Directed Medical Therapy in Chronic Kidney Disease From Tor Biering-Sørensen, MD, MSc, MPH, PhD and team: sciencedirect.com/science/articl…

Wonder what makes #healthcare systems successful? Read this 📑 on #Denmark led by Tor Biering-Sørensen, MD, MSc, MPH, PhD in #GlobalRounds Circulation Economically just society Universal healthcare Strong primary care for every person Enviable clinical & research infrastructure ahajournals.org/doi/full/10.11…

Our recent paper highlighted in JACC Journals

Inflammation and risk of cardiovascular outcomes in atrial fibrillation and flutter patients: A Nationwide Registry Study Adam Femerling Tor Biering-Sørensen, MD, MSc, MPH, PhD CTCPR Trials & CIRL heartrhythmjournal.com/article/S1547-…

🤩Simultaneous publication for NUDGE CKD trial in Circulation #ERA25

Rationale and design of NUDGE-CKD: A nationwide randomized factorial trial of electronic nudges for increasing guideline-directed medical therapy in CKD #ERA25 Evaluating if a single electronic letter can increase GDMT use in patients with CKD. sciencedirect.com/science/articl…

#NUDGECKD in Circulation #ERA25 by Kristoffer Grundtvig Skaarup & Tor Biering-Sørensen, MD, MSc, MPH, PhD Nationwide 2x2 Pragmatic Implementation Mega-Trial 👥 n=22,617 🇩🇰 adults w #CKD 🥼n=1540 General practitioners Electronic nudges did not improve uptake of #RASi or #SGLT2i versus usual care ahajournals.org/doi/10.1161/CI…

Excited to see my brilliant fellow Kristoffer Grundtvig Skaarup present the NUDGE-CKD trial in the Late-Breaking Clinical Trial presentations at ERA2025 in Vienna. A nationwide 2x2 factorial RCT testing patient- and provider-targeted nudges to increase GDMT uptake in chronic kidney disease.

Tor Biering-Sørensen, MD, MSc, MPH, PhD does it again! At #ERA25, a 🇩🇰Nationwide 2x2 Care-Embedded Implementation Trial with >20,000 pts & >1500 practices. No 🔼 in #RASi or #SGLT2i with electronic, #BehavioralScience letters. Brilliant work by Kristoffer Grundtvig Skaarup, mentored by Tor Biering-Sørensen, MD, MSc, MPH, PhD. 🙏🏾 for including me!

Improving the use of GDMT in practice is incredibly challenging Despite hope and prior claims that low-intensity electronic letter nudges to patients or clinicians are effective… No benefit found in this factorial RCT The NUDGE-CKD Trial | Circulation ahajournals.org/doi/abs/10.116…

Rationale, Design, and Baseline char. of KP-VACCINATE out in AmericanHeartJ. ~3.8 Million adults randomized in 2 integrated learning healthcare systems in ~4 weeks. To our knowledge, the 🌟largest RCT ever🌟 & fully embedded in routine case. Results soon sciencedirect.com/science/articl…

This trial builds on fundamental work from 3 Danish 🇩🇰 Nationwide RCTs (NUDGE-FLU, NUDGE-FLU2, NUDGE-FLU CHRONIC) which showed increase vaccination update with CV focused messaging, providing global evidence for this strategy. jamanetwork.com/journals/jama/… Tor Biering-Sørensen, MD, MSc, MPH, PhD Niklas Dyrby Johansen

Excellent meta-research: A trial within a large trial shows that consent form length impacts recruitment. Please consider too much text can exclude vulnerable groups / We need to rethink consent forms, too much information may harm. jamanetwork.com/journals/jama/…

Vaccination as a new form of cardiovascular prevention: a European Society of Cardiology clinical consensus statement academic.oup.com/eurheartj/arti…

New episode this week! We discuss pragmatic trial infrastructure in Denmark, implementation science in nephrology and how new approaches to recruitment can improve access, equity and representation in trials #kidneycompass