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New out in Nature!! With age, women can lose one X chromosome in their leukocytes. What’s the cause/consequence? How does it differ from the loss of the Y chromosome in men? nature.com/articles/s4158… Broad Institute FinnGen FIMM HelsinkiUni National Cancer Institute Cambridge University

Would it kill academia to give us a lab coat ceremony, and postdoc match day, and postdoc graduation just like the MDs? Like just a little celebration as a treat?

Previous papers have shown that drug targets with supporting genetic evidence can have twice the success rate when reaching clinical trials. In our most recent paper (medrxiv.org/content/10.110…), we looked at how data from 23andMe can provide additional genetic evidence. 🧵1/8

All amazing scientists but once again pretty geographically focused: By a quick count 19 of 26 are from Massachusetts or California with 9 of 26 (35% from Harvard or MIT. Great science happens around the nation.

got me interested. Here's a map of all HHMI Investigators. For ref, Illinois and Indiana dots = 1 investigator. Oh and this map doesn't include Alaska or Hawaii but don't worry there aren't any there. Check that SE USA... WV, MO, KY, TN, MS, AL, AR, LA, GA

Interesting paper from 23andMe showing "the minimal contribution of non-additivity in the genetic architecture of adult human height." based on a GWAS of height in 3.6 million individuals. One caveat to note that is here the authors tested epistasis between only a ~1000 common

Journal editors be like

Burnout happens when there is no progress. Burnout also happens when you have no visibility into how dots will connect in the future. Burnout is about not being able to close the loop after putting a ton of effort and not seeing enough results.

GPT is having a profound effect on how students write. Its verbose style, full of cliches and 'fancy', out of place vocabulary is in every paper and draft I read. A few years back, there were grammar errors and awkwardness -- but at least people had their own voice. Now,

Sometimes I think that menu-driven statistical programs should not be available. They provide a false sense of competence and facilitate a garbage in garbage out approach to statistical analysis.

Our blog post on the same work, for the lay reader. blog.23andme.com/articles/genet…

Thank you to our customers and the 23andMe Research team for this work on the genetics of #longcovid medrxiv.org/content/10.110…

So, during the pandemic I had a young angry man who chose not to be vaccinated. He was convinced that his youth and vigour along with some questionable supplements would keep him healthy. He took no precautions and actually attended a COVID party.