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niplav Hope

polis ecology

what's the biological tldr for how antibodies would generate "universal antivenom" from gradually escalating doses?

cashiered from the gamer community (CD-ROM ritually snapped over knee, hard drive thrown out window, etc)

thebes A soldier will fight long and hard for gamer moments and aura.

was recently bitten by horseflies. pain was suprisingly intense but shortlived with no itch. it made me wonder why horseflies and mosquitoes despite having the same lifestyle and ancestry are morphologically so different.

There are many. The most mundane overlooked bottleneck is probably context length. Hundred of billions of dollars deep in the tech tree and we still can't reliably stretch capabilities beyond ~100K tokens without substantial perf degradation. Lesson in that(?).

Zengineer Reinforcement learning is even more difficult to stretch over long context due to credit assignment.

if I stare at this tweet long enough I feel like I understand what pill I had in mind

norvid_studies the use of cat like and dog like are mainly historical. i would almost never pay attention to such namings, e.i. not all bristleworms have bristles not all carnivora are carnivores. also dog-like morphologies show up among feliformes and cat-like ones among carniformes

Rookie wh Jasper Dekoninck Lots of good answers already. I'll just add: P6 this year is very hard. A coach for the US IMO team rated it as one of the three hardest IMO problems since 2000. So, "why LLMs fail" might be overdetermined. 1/ web.evanchen.cc/upload/MOHS-ha…

Rookie wh Jasper Dekoninck It's also the kind of problem we've seen all AI systems struggle with: combinatorics with a geometric flavor. These problems are often a bit off-the-beaten-path. On this one you can use some known theorems on some steps, but the overall approach requires a bit more creativity. 2/

what other questions are like this

May 15th huh

norvid_studies very difficult to say, but arthropods have a printer-like style of limb generation during embryogenesis, its easy for them adjust the number of segments and among dozens of legs some are free to mutate since there is functional redundancy

norvid_studies vertebrates also have this printer style development, but for the spinal cloumn and there is actual heterogeneity in the number of vertebrae animals have. if you want to read about it the keyword is somitic clock

The embryonic development of the centipede Strigamia maritima

norvid_studies Affinity maturation, multiple exposures to diverse antigen can select for broadly neutralizing antibodies People saying V(D)J recombination are incorrect, affinity maturation is largely driven by somatic hypermutation of already-VDJ-recombined B cells

norvid_studies This doesn't usually work, usually you get a polyclonal response against a bunch of different epitopes (this is driven by VDJ recombination) not one super-antibody. This is why people have tried and failed for decades to elicit broadly neutralizing anti-HIV antibodies w/a vaccine