Iannis Aifantis Lior Pachter PubSmear I think the difference is that the high impact journals do EXTREMELY POOR peer review for computation. The current peer review system for comp bio in the higher impact biomedical journals is near useless.

Excited to share our new preprint of single-cell transcriptomics in human infant lungs led by Shawyon Shirazi and jon kropski in partnership with David Frank Nick Banovich Chris Wright: biorxiv.org/content/10.110…

“ceSAR combines cheminformatic techniques with signature concordance analysis to connect small molecules and their targets and further assess their biophysical compatibility using molecular docking”. A fantastic and powerful idea. Congrats Jason and Jarek!

SpliceVarDB: A comprehensive database of experimentally validated human splicing variants #RareDisease #Genetics #splicing cell.com/ajhg/fulltext/…

Let me introduce: InstanSeg 🦠🔬💻👩‍🔬 This *would* have been a short thread about Thibaut Goldsborough’s PhD work… but he solved too many problems. Now it's a long thread about 2 preprints, a whole new approach to cell segmentation & #opensource software to make it easy to use

Transfer of mitochondria via nanotubes from bone marrow stem cells to CD8+ T cells augments cellular metabolism, empowering engineered T cells and tumor-infiltrating lymphocytes to counteract exhaustion and fight tumors more effectively Cell cell.com/cell/fulltext/…

New Review: Jeet Biswas, MD, PhD, Leora Boussi, MD, Stein and Abdel-Wahab Abdel-Wahab Lab Memorial Sloan Kettering Cancer Center describe the current state of understanding of how #RNA processing is dysregulated in #cancer and how this knowledge is being harnessed for therapeutic intent. hubs.la/Q02QZxQ00

Our latest paper is out! In collaboration with Anne Carpenter, PhD, we conducted a systematic high-content screen to understand the role of protein mislocalization in diverse human disorders. 1/ cell.com/cell/fulltext/…

The human lung at microscope scale... We are works of art. nature.com/articles/s4159…

🗨️ WANNA TALK TO YOUR CELLS? Try out CellWhisperer – our new multimodal AI that turns single-cell RNA-seq analysis into a conversation. No coding needed, just chat in plain English. Short walkthrough below. Web app & bioRxiv preprint linked in the thread. Let's dive in! (1/9)

Alternative translation initiation produces synaptic organizer proteoforms with distinct localization and functions dlvr.it/TFTKc8

Super excited to finally post about our RNA foundation model, led by our very own Ali Saberi (not on Twitter), with Hani Goodarzi , Amin Emad , and Vishnu Ram. LoRNA-SH is splice-aware, takes as input the entire pre-mRNA, and models isoform diversity biorxiv.org/content/10.110… 1/n

A team of UC Berkeley chemists have developed a yellow crystalline powder that can pull carbon dioxide from the air, a half-pound of which can absorb as much CO2 annually as a tree. “This is a game-changer,” said a UC Berkeley chemistry professor. trib.al/EgGkLHh

We’re excited to share our latest paper in Nature Communications uncovering a new mechanism behind chemotherapy resistance in AML: nature.com/articles/s4146…

🚨 Great alternatives to BioRender are now available!! 📢 NIAID News offers a collection of public figures and icons for everyone to use. Check it out at bioart.niaid.nih.gov

As of this week, Americans will get automatic refunds if their flights are altered because of a cancellation or significant delay. That’s a big deal for folks who will be flying to visit loved ones this holiday season.

Dive into the intricate connections in the mouse brain! This video showcases 107 reconstructed neurons, thanks to the combined efforts of our teams at the Allen Institute, global collaborators, and tools from Google AI. Imaged using our cutting-edge ExA-SPIM microscope. 🧠✨

Happy Schrödinger day. Let’s hope the cat is alive.

Excited to share BayesTS (shorturl.at/Z1wFi), a new tumor specificity index (measuring how safe a target is) we proposed for drug target discovery. It integrates RNA gene expression, protein staining, tissue essentiality, and many other modalities into a single score. (1/8)

The BayesTS score for all human protein coding genes are available at (github.com/frankligy/Baye…) and the code is freely available at (github.com/frankligy/Baye…), feel free to take a look and we appreciate any feedback. (7/8)