Impressive evaluation of GPT-4 on medical exam questions (eg. USMLEs) from Microsoft/OpenAI Eric Horvitz Harsha Nori Interesting work (section 6.2) to test whether the model saw the exam in its training. They think probably not, but hard to be sure... arxiv.org/pdf/2303.13375…

Excited to share our plans for ADVANCE-TBI, investigating long-term neurological outcomes of traumatic brain injury in UK armed forces personnel bmjopen.bmj.com/content/13/3/e… ADVANCE Study DMRC-Stanford Hall Alexander Bennett @Neurosharp GZ Nicola Fear with thanks to the ADVANCE charity

Very proud and excited about this paper - we present results of the first #genesilencing treatment in #alzheimers disease and show robust dose & time related reduction in tau levels. Phase 2 ongoing! ⁦DRC@UCL⁩ ⁦NIHR UCLH Biomedical Research Centre⁩ #curedementia nature.com/articles/s4159…

Why many Aβ-positive cognitively unimpaired individuals do not develop downstream tau pathology? Our new study led by Bruna Bellaver published in Nature Medicine shows that looking at reactive astrocytes may help start solving this question. rb.gy/y9qkj

Many congratulations to all partners on securing funding for TBI Reporter, an ambitious platform for TBI research David Menon Peter Hutchinson Dr Willie Stewart @Neurosharp ukri.org/news/research-…

A superb innovation from the Imperial cardiology team.

"Associations Between Traumatic Brain Injury and Cognitive Decline Among Older Veteran Men - A Twin Study" Twin study data demonstrating lifelong #BrainHealth consequences of #TBI. n.neurology.org/content/early/…

Pleased to see this comment with @Neurosharp published looking at the great work of the TRACK TBI team on dynamic patient trajectories years post-injury. More to be done to understand things at a mechanistic level but key implications for patient monitoring & treatment trials.

Parker et al. report that head injuries during elite rugby games may result in localised cortical swelling that correlates with astrocytic activation and long-term reductions in cortical thickness. tinyurl.com/4xfb3j5s

Informative discussion of new Alzheimer’s treatments, with Paresh Malhotra Robert Howard on BBC More or Less. A great listen. bbc.co.uk/sounds/play/m0…

Remarkable: thelancet.com/journals/lance…

Semaglutide in nondiabetic adults with obesity - remarkable cardiovascular effects (MI, stroke) with also a significant drop in mortality. Trial in NEJM nejm.org/doi/full/10.10…

This month, PFA CEO Maheta Molango and Chair Omar Beckles visited the Advanced BRAIN Health Clinic at The ISEH 🏃🏽‍♀️🏃‍♀️ in central London. The clinic provides confidential, specialist clinical assessment for mid-life retired male and female professional footballers, and uses data to

If you are a retired player between the ages of 30 and 55 and would like to check your eligibility for a brain health assessment, contact @theISEH Advanced BRAIN Health Clinic. ➡️ iseh.co.uk/patients/clini…

We evaluated the biological variation of 🩸 p-tau (217, 231, 181), Aβ, NfL and GFAP weekly over 10 weeks in healthy individuals aged 40-60. An important read for anyone interested in AD 🩸 biomarkers - there’s much more we need to know beyond AUC’s! alz-journals.onlinelibrary.wiley.com/doi/full/10.10…

Many thanks to esteemed authors especially Andrew Lees and of course The Lancet for helping us write the third in this series of articles on Parkinson’s. authors.elsevier.com/a/1iSC0V-4XL3kI

Great opportunity to join @Neurosharp team at Imperial Department of Brain Sciences as a research assistant, working on late-consequences of military neurotrauma. Do reach out if you'd like to know more about the role. (Closing date 1st April) imperial.ac.uk/jobs/search-jo…

Finger-prick blood testing🩸shows promise to help traumatic brain injury / Alzheimer's diagnosis, as this remarkable technology continues to improve. Wonderful working with Nicholas Ashton Magda Mike Hanna Henrik Paresh Malhotra @Neurosharp & more on it: academic.oup.com/braincomms/adv…