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This morning, Nature published two papers on bridge editing, the new genome engineering technology from @ArcInstitute: nature.com/articles/s4158…, nature.com/articles/s4158…. I'm quite excited about its potential! Since the whole thing is pretty arcane, I fed the blog post

Congrats to Matt Durrant Nicholas Perry Patrick Hsu hnisimasu and colleagues on their bridge recombinase works! Excited to see how this technology progresses. 🧬 Ben Kleinstiver and I highlight their two papers in nature Nature News & Views: nature.com/articles/d4158…

Did you see the bridge RNA papers yesterday? Bacterial transposons promote programmable, RNA-guided DNA recombination. Remarkably, we found that the recombinase was co-opted in archaea and eukaryotes for widspread RNA-guided RNA modification, an essential function in humans!

On the topic of RNA-guided biology emerging from transposons, you won't want to miss this one! In published work led by the talented Tanner Wiegand, we uncovered the presence of pervasive, RNA-guided transcription factors in diverse biological contexts. nature.com/articles/s4158…

A recent & exciting scientific discovery is Bridge RNA - a new class of guide RNAs that could recombine, insert, delete, or invert any 2 pieces of DNA. Discovered by Patrick Hsu, Matt Durrant & Nicholas Perry - here is a great video by Arc Institute which explains this new modality.

Hey folks, I know most deadlines are fast approaching, but I am applying for assistant professor positions this cycle, and I would appreciate recommendations for open positions! My research plan is focused on MGEs, genome engineering, and applying AI to biological discovery.

Congratulations Alison! Looking forward to seeing what people do with your engineered integrases in stem cells and T cells. Check out Alison Fanton exciting thesis work here: biorxiv.org/content/10.110… nature.com/articles/s4158…

me with deepresearch: “find obscure biochemistry papers from the 1960s and 70s that have very weird but intriguing results, and there have been no follow up experiments since”

We are excited to report the discovery of TIGRs, a widely-occurring RNA-guided system found in bacteria and their viruses. TIGRs consist of a peculiar repeat region which is transcribed into RNA and processed into multiple guide RNAs to direct TIGR-associated proteins to their

Big deal: Bridge recombinases are now working in human cells. Preprint here: biorxiv.org/content/10.110…

The Case for Bridge Editors Many people seem confused about the gene-editing tool released by Arc Institute. How does it work and why does it matter? Fair questions. The preprint is not easy to understand, and the reasons for inventing a new gene-editing tool are not obvious...

In the ocean, a single-celled organism travels ~50 meters vertically by rapidly inflating its body with water. The dinoflagellate, Pyrocystis noctiluca, does this by swelling six-fold in size in just ten minutes. This fast expansion drops cell density. When the cell becomes less