Researchers at ETH Zurich have combined two #GeneEditing methods. This enables them to quickly investigate the significance of many #GeneticMutations involved in the development and treatment of #Cancer. brnw.ch/21wOzs3

One of the major challenges in human genomics is the functional assessment of variants. Base and prime #CRISPR genome editing is making a big difference for meeting that challenge, as exemplified in this new report Nature Biotechnology nature.com/articles/s4158… Randall Platt

Randall Platt Olivier Belli Kyriaki Karava ETH Zurich D-BSSE, ETH Zurich Basel Research Centre for Child Health Universität Basel @NCCR_MSE Using CRISPR to decipher whether gene variants lead to cancer #NBTintheNews via ETH Zurich ethz.ch/en/news-and-ev…

Randall Platt Olivier Belli Kyriaki Karava ETH Zurich D-BSSE, ETH Zurich Basel Research Centre for Child Health Universität Basel @NCCR_MSE Combining base and prime editing to decipher which gene variants lead to cancer #NBTintheNews via Genetic Engineering & Biotechnology News genengnews.com/topics/cancer/…

And read the News & Views from Francisco J. Sánchez-Rivera highlighting this work, along with related work published in Nature Biotechnology from Randall Platt and colleagues, (nature.com/articles/s4158…), here: nature.com/articles/s4159…

Thrilled to see our work out in Nature Methods today! We applied prime editing to multiplexed dropout screens and benchmarked the tool’s ability to induce phenotypes when installing premature stop codons in essential genes.