I had a lot of fun working on this with Peter Sims and Pranay Talla! Basically we realized the 10x Genomics ATAC+GEX kit could be a gDNA+GEX kit if fed nucleosome depleted nuclei. Scalable co-sequencing of RNA and DNA from individual nuclei biorxiv.org/content/10.110…

As Ben Hobson clearly lays out, something is real 🐠🐟🎣🐟🐠 about this synaptosome work. Either that or, with 180E6 molecules, we've all been doing synaptosome work without realizing it. nature.com/articles/s4158…