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nature.com/articles/d4158… This is a nice, simple, schematic of the major phylogenetic events of SarsCoV2

Excited to be going to the celebration of Joan Steitz - 50 years at Yale. What a star! 🌻ﾅょωﾚよ″丶)ょぅすﾚﾅ🌻 @yale

I just completed a survey on Genetics Society of America journals. If you're a geneticist, you can too. #GSASurvey22 e.genetics-gsa.org/Prod/link-trac…

What I want to know is who redefined "junk DNA" to include regulatory sequences. Conserved regulatory sequences are not junk DNA. beta.nsf.gov/news/butterfly…

Grateful to NIDDK NIH Intramural for granting me tenure at #NIH! Special thanks to current and former members of the lab for their essential contributions, Susan Buchanan and Mike Krause for their guidance and mentoring, our generous collaborators and colleagues in #RNA #tRNA.

I'm looking at Post.news. You can also sign up for Post. post.news/?r=U8tZ4

Another very original insight from Christine Mayr! "a novel mode of protein activity regulation"

This is a nice story about genetic analysis leading to a cure. STAT4 variants contribute to disabling pansclerotic morphea, and it looks like JAK inhibitors are a potential treatment. I've been hearing about it from Brynja Matthiasardottir for a while now. genome.gov/news/news-rele…

Join ISMB/ECCB 2023 in Lyon, France, or virtually July 23-27! I'm not going to make it this year, but ISMB is always a great conference. Let's shape the future of our field together! invt.io/1txbkeu1w6y #ISMBECCB2023 #ComputationalBiology #Bioinformatics #Conference

I'm starting as one of 23 Associate editors in this new section.

OBITUARY Michael Ashburner (1942–2023) cell.com/current-biolog…

Splicing variation shapes mammalian complex traits. "more sVariants were called than eVariants, and ... multi-tissue sVariants alone explained a similarly large proportion (66%) of heritability to eVariants and sVariants jointly (69.2%)." Also - many trans sVariants!

Predicting the impact of rare variants on RNA splicing in CAGI6. New paper from us ⁦CAGI⁩ #CAGI6 thank you ⁦Jenny Lord⁩ ⁦Carolina Jaramillo Oquendo⁩ ⁦Htoo Aung Wai⁩ ⁦Steve Mount⁩ ⁦Predrag Radivojac⁩ link.springer.com/article/10.100…

You and Jenny Lord did a great job putting this together!

Want to understand how splicing decisions are actually made in the cell based on pre-mRNA sequence? PhD student Kayla McCue has been hard at work modelling just that, & we're very excited to announce that now you can read about it in her new preprint! biorxiv.org/content/10.110…

Rosaceae (berries, stone fruits, apples, and more) has amazing diversity in fruit development. Zhongchi Liu has vast omics data that captures much of this variation. Now, Muzi Li has put it on a nice database. rosaceaefruits.com academic.oup.com/hr/article-abs… Glad to have helped.

Fitbit users are unanimously opposed to removing the browser interface. Many of us feel strongly about it. community.fitbit.com/t5/Fitbit-com-… The claim that data and features of the dashboard are available in the app is a lie. Why did they do this? It makes no sense. #Fitbit is failing.

RNAseq is commonly performed. We compared N=30 wild-type Bl6 mice to an N=30 heterozygotic knockout with a phenotype, and then downsized. We found you need at least an N= 8-12 to avoid a >50% false positive rate. A 2nd line confirmed the finding. biorxiv.org/content/10.110…

I loved the TAGC (The Allied Genetics Conferences). This is really too bad. Genetics Society of America

RFK Jr. is apparently going to tell Congress today that HHS doesn't need much money. The cuts have damaged important science. If he says it's all waste and duplication he's either lying or doesn't know his job. Rep. Jodey Arrington Congressman Josh Brecheen Michael Burgess, MD Buddy Carter