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I’m excited to share my preprint on how Kiwa is used by bacteria to defend against phage infection! Graphical abstract and thread below 👇👇👇 biorxiv.org/content/10.110…

Mechanism of the Hachiman immune system finally deciphered A beautiful study from the Doudna lab shows that Hachiman is a genome integrity sensor biorxiv.org/content/10.110… Congrats @doudna_lab and colleagues!

The 2024 symposium on the immune system of bacteria is over. Thank you everyone for the great science, discussions and vibes. See you next year in Paris on April 8th-10th 2025.

Our paper on the biochemical understanding of an engineered Cas9 (by directed evolution) is officially out Cell. “Rapid DNA unwinding accelerates genome editing by engineered CRISPR-Cas9” cell.com/cell/fulltext/… Following our previous study on the development of an

I am excited to share that our paper “Rapid DNA unwinding accelerates genome editing by engineered CRISPR-Cas9” from @doudna_lab is out in Cell! authors.elsevier.com/sd/article/S00…

🚨 New preprint alert! I am excited to present a collaboration between the Doudna Lab and Zev Bryant lab, with co-first authors Noor Al-Sayyad and Kevin Wasko and me. Curious about what drives high-efficiency genome editing by Cas9? Let’s dive in!👇🧵biorxiv.org/content/10.110…

🦠🧬Our paper is live Cell: Genome integrity sensing by the broad-spectrum Hachiman antiphage defense complex authors.elsevier.com/sd/article/S00… Through structural, genetic and microbiological approaches, we show that Hachiman degrades DNA… by sensing low integrity DNA.

Now online! Genome integrity sensing by the broad-spectrum Hachiman antiphage defense complex dlvr.it/TFFdc1