
michele pagano
@paganolab
Studying the molecular mechanisms underlying the degradation of cellular regulatory proteins by the ubiquitin system and inform about cancer vulnerabilities
ID: 1129741897717768193
https://www.paganolab.org/ 18-05-2019 13:33:52
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Delighted to announce that our postdoctoral fellow, Sehbanul Islam, has been awarded the Rising Star Award from the CHOP Research Institute Normal and Malignant Hematopoiesis Research Affinity Group for his outstanding research and publication. Congratulations🥳 Sehbanul Islam



Branched #ubiquitin has important roles in cell signaling but are very challenging to study due to complexity & lack of tools. We tackle this challenge in our latest study NatureStructMolBiol developing a toolkit enabling discovery of molecular players and pathways rdcu.be/dM5nn






Check out our latest review regarding the biology of RAS GTPase effectors! It was fun to write this with Alessandro Mozzarelli and Simanshu Dhirendra for Molecular Cell. Bottom line: lots of knowledge on these proteins, but many questions that remain to be answered. cell.com/molecular-cell…




I am deeply honored to be named one of this year's recipients of the prestigious Lloyd Old STAR grant of the Cancer Research Institute . To be included in the esteemed list of previous and current awardees is humbling and inspiring. I am grateful for this incredible opportunity🙏

A new study led by researchers at NYU Langone Health and Perlmutter Cancer Center at NYU Langone Health identified a gene signature that one day may serve as a biomarker of severe side effects from immunotherapy for #melanoma. Clinical Cancer Research Learn more about the study: aacrjournals.org/clincancerres/…



Excited to share our latest work combining VHL and CRBN in a single trivalent PROTAC to boost protein degradation. Great #TPD collaboration with @georg_e_winter and Kristin Riching, led by Adam Bond Miquel & Celia in each lab Centre for Targeted Protein Degradation CeMM Promega Corporation doi.org/10.26434/chemr…




Fantastic work by Nikol Dibus and an excellent collaboration with Michele Pagano michele pagano and Ondrej Stepanek Ondrej Stepanek - Lab of Adaptive Immunity! Hopefully, more journals will endorse papers focused on addressing the confusion published across all levels. embopress.org/doi/full/10.10…
