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A step-by-step tutorial for detecting collective phenomena in time-lapse images in a new #OpenAccess article in Methods in Microscopy from De Gruyter Brill ➡️ @degruyterbrill.bsky.social Benjamin Grädel Paolo Armando Gagliardi PertzLab, doi.org/10.1515/mim-20…

Ever wondered how stem cells ensure a balance between cell fates in the gut?⚖️Turns out, they’ve got rhythm!🎶Our latest research reveals that NOTCH-driven oscillations regulate stem/progenitor cell abundance and specify secretory subtypes. Check it out: biorxiv.org/content/10.110…

The field often discusses Rho signaling in controlling actomyosin assembly and assumes that when Rho signaling ceases, actomyosin disassembles. But is this really true? 🤔

Happy to share this work from my postdoc where it's illustrated how breadth and depth 3D-cancer models contribute to successful translation of drug discovery efforts to the clinic.  Proud of being part of this team! Istituto di Candiolo - FPO IRCCS Fondazione Piemontese per la Ricerca sul Cancro nature.com/articles/s4146…

Great to see the new #Lumiplate Thomas!

Check out this new pixel classifier from our lab!!

Super cool work of David Gonzalez-Martinez and Lukasz Bugaj, showing the role of EML4-ALK assemblies in MAPK/ERK signaling, and the potential of targeting apoptotic ERK waves in combination with ALK inhibition

Happy to announce our new preprint "A green lifetime biosensor for calcium that remains bright over its full dynamic range" which is now available on bioRxiv: biorxiv.org/content/10.110… Why yet another biosensor for Ca2+? Here's a thread 🧵

Our work on FGF/ERK signaling in 2D gastruloids is now published as a reviewed preprint in Elife (revisions to come) doi.org/10.7554/eLife.… eLife - the journal

Glad to share our last manuscript on a luminescent sensor we created to unveil novel potentially actionable regulators of β1 integrin activation in vascular endothelial cells and angiogenesis. Great collab w/ Jieqing Zhu Lab Versiti Blood Research Institute Sara Zanivan doi.org/10.1016/j.celr…

PREPRINT OUT ✨ "hack" your microscope to work as a 3D printer! print micrometer sized features at cm scale. a method for easy and cheap microfabrication, with a focus on biological applications. THREAD ↓ biorxiv.org/content/10.110…

#StandUpForScience

🧠Recently published in Bioinformatics Advances: "A Kolmogorov metric embedding for live cell microscopy signaling patterns"    Read more here: doi.org/10.1093/bioadv… Authors include: Layton Aho  Paolo Armando Gagliardi

Our review on apoptosis-induced ERK waves is out in Seminars in Cell & Developmental Biology! Thanks to PertzLab, Maciej Dobrzynski & all colleagues studying ERK dynamics! sciencedirect.com/science/articl…

Our work on mesoderm development in 2D gastruloids is now published in Nature Methods: nature.com/articles/s4159…

Are you using phospho-ERK staining to infer Ras/MAPK signaling history of fixed cells? Check out our recent work demonstrating how this can be misleading, and how to get more spatio-temporal information out of immunofluorescence staining. nature.com/articles/s4146…

Superb article from Abhineet Ram and John Albeck demonstrating that single-cell ERK history can be reconstructed by end-point measurements!

Very happy that our work that led to the identification of the molecular target for the anti-malarial Gamhépathiopine has been published today! Thank you to Susan Wyllie, to the Mode of Action Group and to all co-authors for this fruitful teamwork!

The pan-cancer proteome atlas, a mass spectrometry-based landscape for discovering tumor biology, biomarkers, and therapeutic targets dlvr.it/TLyB5j

Preprint Alert 🚨 Check out the latest piece of work from the Deitsch lab, where we characterized the sophisticated molecular layers controlling var2csa expression and antigenic variation in P. falciparum