Pleased to share our story Nature Communications on the discovery of genes regulating #hPSC pluripotent identity versus cell fitness through genome-scale CRISPR-Cas9 KO screens, as part of the #MorPhiC initiative aiming at establishing the function of human genes. rdcu.be/dXi72

Women lose >90% of their #eggs by their mid-30s, with persistent #DNADamage driving this loss. But why isn’t this damage repaired? Our new work in Current Biology, led by Ninadini Sharma, reveals the causes of high DNA damage in aged oocytes.🧬💥 bit.ly/48e35Ee (1/13)

Fantastic review on CTCF’s crucial role in X-chromosome inactivation and chromatin organization

Privileged to be part of this fantastic work about X chromosome upregulation in various contexts.Thank you very much SrimontaGayen_Epigenetics lab IISc Bangalore for providing me this wonderful opportunity.Hearty congratulations to Hemant Chandru Naik and others in the team.

We are excited to share our latest work: Transposable elements are deregulated in #Preeclampsia, which correlates with type-I IFN levels. "TE signature in maternal cell-free RNA can predict preeclampsia before the appearance of symptoms" biorxiv.org/content/10.110…

Happy to share our latest paper, a reference atlas of human development from zygote to gastrulation. Further developed an online reference tool to call cell lineages in an easy and automated manner. Fantastic work by ⁦Cheng Zhao⁩ and authors nature.com/articles/s4159…

Adenoviral delivery of the CIITA transgene induces T-cell-mediated killing in glioblastoma organoids 👉buff.ly/3V9vUwl 🥼Aurélie Poli Eliane Klein Antonio Marchini Anna Golebiewska Anuja Lipsa, PhD #Organoids #TumourOrganoids #Oncolytic #Immunotherapy

Please retweet! We are looking for outstanding postdocs interested in studying cancer evolution! 🌟 See our recent work nature.com/articles/s4158… 🔬 Research Areas: 1️⃣ APOBEC3 induced mutations & RNA editing in cancer evolution. 2️⃣ Extrachromosomal DNA & therapy resistance. 3️⃣

🚨 Exciting news! 🚨 Our latest paper is now published in Science Advances! 🎉 "Transcription-coupled changes in genomic region proximities during transcriptional bursting" 👉 Read it here: science.org/doi/10.1126/sc…

Our paper "CD4+FOXP3Exon2+ regulatory T cell frequency predicts breast cancer prognosis and survival" has been published on Science Advances! 1/7 science.org/doi/10.1126/sc…

I’m very excited about this collaborative project! We managed to significantly scale up and streamline human blastoid generation without the use of feeders. reNEW GrazianoMartello The Leeboratory @vincentpasque Nicolas Rivron

Open call! The EMBO Global Investigator Network supports group young leaders who are setting up their laboratories in Chile, India, Singapore or Taiwan. Apply by 1 May: embo.org/funding/fellow… #ResearchFunding #LifeSciences

I am super proud to share the first Andergassen Lab preprint! Here, we introduce a new framework to decode the non-coding genome, led by the outstanding work of Tim Hasenbein and co-authors Sarah Hoelzl, Stefan Engelhardt TU München DFG public | @[email protected] Non-coding RNA in the cardiovascular system 👇🧵

It was an incredible experience speaking about #StemCells: Biology and Applications at the Indian National Science Academies lecture workshop held at Bishop Heber College. I thoroughly enjoyed engaging with the young minds there Indian National Science Academy (INSA) IISc Bangalore DSTIndia

Online now!✨RESEARCH: Sarah Hoelzl et al demonstrate that aging promotes reactivation of the inactive X chromosome in mice, and catalog escape genes using multi-omics Daniel Andergassen nature.com/articles/s4358… rdcu.be/ekm0I

Here it is again! Shreya lucidly describes our Nature Communications paper where she is a coauthor. Led by Sabnam Rahman. Collaboration with Shantanu Sengupta CSIR-IGIB. Also Simran Motwani Govind Prakash. Funding Department of Biotechnology Anusandhan National Research Foundation BRIC-NII, Rajesh Gokhale Dr Jitendra Singh

It’s been a real joy to contribute to this brilliant piece of work. Huge congratulations Debabrata Laha this is a fantastic achievement!" Nature Chemical Biology IISc Bangalore

Published now Genome Research how Xist upstream elements regulate gene expression. Excellent work by Sudeshna Majumdar Thanks IISc Bangalore Anusandhan National Research Foundation Department of Biotechnology EMBO YIP for support. genome.cshlp.org/content/early/…

Our new preprint, led by Max Moonier and Luke Thomas, on CRISPR barcoding + eDNA for multigenerational coral tracking (finally I get to work on corals! 🪸) biorxiv.org/content/10.110…

🚨JOB ALERT🚨 PLEASE SPREAD and RT We are building a small expert team within the BökeLab at Centre for Genomic Regulation (CRG) Biomedicina BCN to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility. See below 2 calls👇