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Excited that our work, led by Kun Leng, is out today in Nature Neuroscience today: CRISPRi screens in human iPSC-derived #astrocytes elucidate regulators of distinct inflammatory reactive states nature.com/articles/s4159…

Just opened: faculty search at the UC San Francisco Institute for Neurodegenerative Diseases Institute for Neurodegenerative Diseases. Join our vibrant, interdisciplinary & collaborative research community! Applications from women & underrepresented groups strongly encouraged. See details here: aprecruit.ucsf.edu/JPF04211

I'm looking for an SRAI/II (tech) to work with me on CRISPR screening in microglia! Particularly interested in candidates with experience working with mice as we move towards in vivo screens! Kampmann Lab UC San Francisco sjobs.brassring.com/TGnewUI/Search…

It’s alive on BioRxiv! Super excited to present our paper on CRISPRi-based screens in 3D neuron-astrocyte-microglia co-culture (iAssembloids) to examine neuron-glia interactions. Description of this work in the thread below! Too many words! (1/8) biorxiv.org/content/10.110…

I'm very excited to release this project I've been working on for about a year or so now! gia is a high-performance genome interval arithmetic toolkit, written in #rustlang 🦀, with significant performance increases (2x-20x) over #bedtools and #bedops. biorxiv.org/content/10.110…

We’re excited to share Polygraph, a Python framework for evaluating native and synthetic DNA regulatory elements! @lal_avantika gokcen biorxiv.org/content/10.110…

Happy holidays from the Kampmann Lab! Wishing you peace, happiness, health and success for 2024.

Have you ever wanted to profile how a molecular pathway affects neuronal activity, but didn't know where to start? I'm excited to share "A Massively Parallel CRISPR-Based Screening Platform for Modifiers of Neuronal Activity" 1/ biorxiv.org/content/10.110…

Excited to share a BIG update from the Kampmann Lab to our previous preprint led by the fearless Bren, now a graduate student in the The Gu Lab at Harvard. We find that in inflammatory reactive astrocytes, mTOR-dependent endolysosomal remodeling leads to (1/3)

I am excited to share our work in which we conducted a CRISPRi-based screen to assess 102 Autism Spectrum Disorder (ASD) risk genes in microglial uptake of synaptic material! (1/7) biorxiv.org/content/10.110…