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Have you ever wondered whether age-associated immune defects can be corrected? I am SUPER excited to share our new study from Jonathan Kagan Lab where we found that vaccines containing DC hyperactivators enables CD4+ T cells to eradicate tumors. authors.elsevier.com/a/1jFOm_278y%7…

Online now: A metabolic switch orchestrated by IL-18 and the cyclic dinucleotide cGAMP programs intestinal tolerance dlvr.it/T8XsgH

Check out Jeff’s newest paper in JMR on how AlphaFold doesn’t always get structures right: sciencedirect.com/science/articl… #NMRchat #Biophysics #JMagRes

For 25 years, the Toll-like Receptor pathway was considered a series of distinct protein complexes that drive inflammation. Today, we report that the entire pathway, from receptor to transcription factor, is executed from within one complex—the myddosome. nature.com/articles/s4158…

The pros and confs of IL-18 activation dlvr.it/T9ZjDn

Excited to share our newly published preview in Immunity covering recent insights into IL-18 activation! There is still much to learn about the pro(domains) and conf(ormations) of IL-1 family cytokines! Julie Andries Savvas Savvides Lab doi.org/10.1016/j.immu…

De novo creation of an innate immune LPS receptor. Anh Cao identified the principles of LPS detection by caspase-11, revealing the CARD as a bipartite lipid binding module. This knowledge allowed us to convert an ancient CARD-like protein into a functional LPS receptor.

Excited to share the latest from the @MarsonLab! An investigation of context-specific gene regulation in T cells, which led to dynamic mechanisms required to control T cell rest and activation. Published today in nature thanks to the work of many! nature.com/articles/s4158…

Introducing Dr. Anh Cao! So proud of this outstanding scientist, who defended his thesis today. Harvard Medical School Anh Cao

Anyone left on Science Twitter who has spike specific CD8+ T cells? Wonder how you made them? Wonder no more. #27 ICIS 🦋 @cytokinesociety.bsky.social Jonathan Kagan Ivan Zanoni biorxiv.org/content/10.110…

Short IL-18 generated by caspase-3 cleavage mobilizes NK cells to suppress tumor growth nature.com/articles/s4159… Nature Immunology

🚨New paper alert! 🚨 Our latest work in Immunity shows that Ark313, an evolved AAV variant enables in vivo genetic engineering of murine T cells! 🧵👇 sciencedirect.com/science/articl…

Now we know a major function of #Granzyme K is #extracellular to activate the #complement cascade. Out now nature from Carlos Donado and Michael Brenner. Harvard Medical School Brigham and Women's Hospital Harvard Immunology nature.com/articles/s4158…

Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants nature.com/articles/s4159… Nature Immunology seth masters Shouya Feng

Finally, our study on caspase-11 and its CARD-recognized molecular pattern is out in Science Advances! A small step, but we hope it opens new directions for studying caspase-11 and its ligands. 🔬🚀 #Immunology #Caspase11 #ScienceAdvances 🔗 science.org/doi/10.1126/sc…

New insights into the noncanonical inflammasome point to caspase-4 as a druggable target Interesting perspective by Judy Lieberman, Prof. Hao Wu, and colleagues Nature Rev Immunol nature.com/articles/s4157…

Ever wondered where NLRP3 needs to be in the cell to activate the inflammasome? Turns out, it does not really matter. Check out our latest study in Nature Communications: nature.com/articles/s4146… See 🧵👇 1/9

Congrats to Gladstone Postdoc Pascal Devant who was named a 2025 Jane Coffin Childs Fellow! #JCCFellow bit.ly/4noZSZZ