You can see the paper here: rdcu.be/dHS5C

The β-subunit of tryptophan synthase is a latent tyrosine synthase by Patrick Almhjell, Kadina Johnston, Nick Porter, Jennifer L. Kennemur, Vignesh C. Bhethanabotla, Julie Ducharme, and Frances Arnold at Caltech Chemistry & Chemical Engineering in Nature Chemical Biology nature.com/articles/s4158…

Really neat development in the area of biocatalysis for non-standard amino acid synthesis

What an honor to be chosen for the Priestley Medal. #Enzymes are the best chemists, of course, but the Priestley medalists are no slouches...and include many of my colleagues Caltech Chemistry & Chemical Engineering. Thank you!

I am excited to share our latest discovery which is out now in J. Am. Chem. Soc.! This study uncovers how engineered hemoproteins can leverage biological nitrogen cycle intermediates for enzymatic C–H amination, opening new paths towards sustainable synthesis. pubs.acs.org/doi/10.1021/ja…

Happy to share that our work "A combinatorially complete epistatic fitness landscape in an enzyme active site" by myself, Patrick Almhjell, Dr. Ella Watkins-Dulaney, Grace Liu, Nick Porter, Jason Yang, and Frances Arnold is now out in PNASNews! (1/15) pnas.org/doi/10.1073/pn…

Was great to be a part of this project! Kadina put together a great sequence-fitness dataset, and it’ll be particularly useful for testing machine learning methods!

Great work by Kadina Johnston and her team--here is a complete enzyme 4-site dataset for #ML4proteins, folks! #enzyme.

Have you ever wondered about how epistasis affects protein engineering efforts? In this case study, we created a combinatorial fitness landscape to explore just that. I am so proud of the work that Kadina Johnston (and everyone else!) put in to make this project a reality. Check it out!

The Hagler lab is hiring a research technician/assistant!!! Please consider applying if you are interested in RNA structure, RNA-protein interactions, and drug discovery. tamus.wd1.myworkdayjobs.com/en-US/TAMU_Ext…

Our work describing extensive gene divergence on laboratory timescales with upgraded OrthoRep systems is now out in Science Magazine here - science.org/doi/10.1126/sc…. X thread describing the preprint is quoted below. Congratulations to Gordon Rix and team!